SERUM CHOLESTEROL AND TRIGLYCERIDE VALUES OF THE NCRR WHHL RABBIT COLONY

兽医资源计划，国家研究资源中心， 建立了一只渡边遗传性高脂血症(WHHL)兔 繁育群体 作为研究人员需要该动物模型用于研究的资源 低密度脂蛋白引起的家族性高胆固醇血症 感受器缺陷。 本项目的目的是表征血清胆固醇和 美国国立卫生研究院WHHL兔群的甘油三酯值。采集了血液 在8周、3个月、7个月和12个月时从WHHL兔 几个月大的孩子。分析了血清中的脂蛋白胆固醇和 甘油三酯。已经开发了一种计算机程序来追踪谱系 的影响，从而有可能评估 基因对胆固醇和甘油三酯值的影响。总血清 胆固醇值在310至1251毫克/分升之间，平均值为828毫克/分升。 低密度脂蛋白(低密度脂蛋白)的胆固醇值从70到 1185 mg/dl，平均630 mg/dl。血清甘油三酯测定值范围 从… 107~959 mg/dl，平均394 mg/dl。似乎有一种 老年人血清甘油三酯水平与性别的关系 兔子。中庸之道 男性和女性甘油三酯浓度分别为510 mg/dl和309 mg/dl， 分别进行了分析。

The Veterinary Resources Program, National Center for Research Resources, has established a Watanabe heritable hyperlipidemic (WHHL) rabbit breeding colony as a resource for investigators requiring this animal model for use in human familial hypercholesterolemia due to a low density lipoprotein receptor defect. The purpose of this project is to characterize the serum cholesterol and triglyceride values of the NIH WHHL rabbit colony. Blood was collected from WHHL rabbits at eight weeks, three months, seven months, and twelve months of age. The serums were analyzed for lipoprotein cholesterol and triglycerides. A computer program has been developed to track pedigrees of the WHHL rabbits, making it possible to evaluate the influence of genotype on cholesterol and triglyceride values. Total serum cholesterol values range from 310 to 1251 mg/dl with a mean of 828 mg/dl. The low density lipoprotein (LDL) cholesterol values range from 70 to 1185 mg/dl with a mean of 630 mg/dl. Serum triglyceride values range from 107 to 959 mg/dl with a mean of 394 mg/dl. There appears to be a correlation between serum triglyceride concentration and the sex of the rabbit. The mean male and female triglyceride concentrations were 510 mg/dl and 309 mg/dl, respectively.