THE ANALYTICAL CHEMISTRY OF NEW ANTICANCER DRUGS

本项目的目标是研究和开发分析型计算机 方法：(1)建立新化合物的结构和纯度 抗肿瘤药物及其代谢物，(2)物理化学测定 抗癌新药的性质，(3)定量药物及其应用 生物样品中的代谢物，以阐明药理和 药代动力学测定；(4)药动学机理研究。 潜在有用的合成变换。质谱学，气体 单独或单独使用的层析和高效液相色谱 结合起来，都是强调技巧的。当前感兴趣的复数 是环戊烯基胞嘧啶(生物化学、临床前药理学和 方法发展)、卡宾/水合卡波定(合成和分析 特性)、六亚甲基双乙酰胺(片剂生物等效性和 药代动力学)和修饰核苷(分析表征)。

The objective of this project is the research and development of analytical methods which are used to: (1) establish the structure and purity of new antitumor agents and their metabolites, (2) determine physical and chemical properties of new anticancer drugs, (3) quantitate drugs and their metabolites in biological samples to elucidate pharmacology and to determine pharmacokinetics, and (4) study reaction mechanisms of potentially useful synthetic transformations. Mass spectrometry, gas chromatography and high-performance liquid chromatography, either alone or in combination, are emphasized techniques. Compounds of current interest are cyclopentenyl cytosine (biochemistry, preclinical pharmacology and methods development), carbodine/ isocarbodine (synthesis and analytical characterization), hexamethylene bisacetamide (tablet bioequivalence and pharmacokinetics) and modified nucleosides (analytical characterization).