STUDIES OF ACQUIRED IMMUNE DEFICIENCY SYNDROME

一项新的工作集中在艾滋病的动物模型上。 1987年8月。正在建立两个模式系统：1)a 使用猴免疫缺陷病毒(SIV)的灵长类动物模型，以及， 2)猫T淋巴细胞嗜淋巴病毒(FTLV)猫科动物模型。 这两种病毒都属于慢病毒亚家族，并可诱导 慢性迁延性感染与免疫缺陷 各自的主机。SIV在基因上与人类密切相关 艾滋病病毒，而FTLV似乎与 基于缺乏抗原性的人类或灵长类病毒 反应性(序列数据不可用)。因此，这两个模型 系统将允许进行深入的检查(体外和体内) 分子生物学、发病机制和宿主免疫反应， 并将提供机会进行系统的评估 免疫预防和抗病毒的候选疫苗方法 治疗。

A new effort concentrating on animal models of AIDS was undertaken in August, 1987. Two model systems are being established: 1) a primate model using the simian immunodeficiency virus (SIV), and, 2) a feline model using the feline T-lymphotorophic virus (FTLV). both of these viruses belong to the lentivirus subfamily and induce chronic persistent infection and immunodeficiency in their respective hosts. SIV is genetically closely related to the human AIDS viruses, while FTLV appears to be much less related to the human or primate viruses based on a lack of antigenic cross reactivity (sequence data is not available). Thus, these two model systems will allow an in-depth examination (in vitro and in vivo) of the molecular biology, pathogenesis, and host immune responses, and will afford the opportunity to evaluate systematically candidate vaccine approaches to immunoprophylaxis and antiviral therapies.