PHARMACODYNAMICS OF SMOKED DRUGS OF ABUSE

吸烟路线是一种有效的药物输送方式。无数种药物 包括可卡因、大麻在内的滥用药物都是通过这种途径实施的， 苯环利定、海洛因和冰毒。方法位于和下 吸食滥用药物在人体志愿者中的药效学。 有近期滥用感兴趣药物史的健康受试者 吸烟路线将参与研究。以下是知情人士 同意后，受试者将在受控范围内吸食低剂量的药物 评估手术安全性的条件。然后，受试者将 参与吸烟与安慰剂对照的双盲对照研究 静脉给药静脉给药行为和生理测量 随着时间的推移，生物样本将被收集。这些数据将 为我们理解药理作用提供了重要信息 这些药物通过吸烟途径的作用。

The smoking route is an efficient means of drug delivery. Numerous drugs of abuse are administered by this route including cocaine, marijuana, phencyclidine, heroin and methamphetamine. Methods are under and pharmacodynamics of smoked drugs of abuse in human volunteer subjects. Healthy subjects with a recent history of abuse of the drug of interest by the smoking route will participate in the studies. Following informed consent, the subjects will smoke a low dose of the drug under controlled conditions to assess safety of the procedures. The subjects then will participate in a double blind, placebo controlled study of smoked versus intravenous administration of drug. Behavioral and physiological measures and biological samples will be collected over time. These data will provide important information to our understanding of the pharmacologic actions of these drugs by the smoking route.