PHARMACOKINETICS AND PHARMACODYNAMICS OF OPIATE ANALGESICS

单次肌肉注射阿片类药物的效果 (海洛因、吗啡、氢吗啡酮、可待因、羟考酮、羟吗啡酮)和 丁丙诺啡在男性志愿者中的舌下研究 确定血液和唾液水平与药理学的关系 效果。此外，这项研究是为了确定一种新陈代谢 海洛因滥用的标志可以在尿液和其他生物中发现 体液。 受试者是有海洛因滥用史的健康男性。知情者 得到了医院的同意，所有的手术都得到了医院的批准 学院评审委员会。总共三次测试剂量(安慰剂和两次 有效剂量)按随机顺序给药。制定了试验措施。 24小时后收集7天的体液 测试。对生物体液进行药物和代谢物分析 层析和免疫分析技术。 这项研究的意义在于唾液作为一种 用于检测滥用药物和表征药物滥用的新测试介质 海洛因等代谢物标志物排泄的时程 尿液和唾液中的鸦片类药物。

The effects of single doses of intramuscularly administered opiates (heroin, morphine, hydromorphone, codeine, oxycodone, oxymorphone) and sublingual buprenorphine were studied in male human volunteers in order to determine the relationship of blood and saliva levels to pharmacologic effects. Additionally, the study was performed to determine if a metabolic marker for heroin abuse could be found in urine and other biological fluids. The subjects were healthy males with a history of heroin abuse. Informed consent was obtained and all procedures were approved by the hospital Institute Review Board. A total of three test doses (placebo and two active doses) were administered in random order. Test measures were made for 24 hours and biological fluids were collected for 7 days after each test. The biological fluids were analyzed for drug and metabolites by chromatographic and immunoassay techniques. The significance of this study lies in the potential value of saliva as a new test medium for detection of drugs of abuse and the characterization of the time course of excretion of metabolite markers for heroin and other opiates in urine and saliva.