BEHAVIORAL/PHARMACOLOGIC FACTORS IN NICOTINE REPLACEMENT FOR TOBACCO DEPENDENCE

尼古丁polacrilex（口香糖）一直在调查中， 替代烟草释放的尼古丁，也是一种方便的药物 提供了一个更普遍感兴趣的模式的管理模式 药物依赖研究人员的研究 有效使用尼古丁 临床环境中的更换策略要求进行 基础研究，以评估各种参数，如剂量和 衡量依赖性。 在过去的一年里，我们研究了时间 尼古丁在口腔粘膜中的吸收过程 polacrilex（口香糖）的使用在我们评估的第二项研究中。 初步分析 的口服动力学研究表明， 通过口腔粘膜的吸收发生在咀嚼的30秒内。 对可能的种族差异研究的初步分析表明， 对牛奶不耐受的人（即，许多非洲人 和亚洲传统）产生升高的呼出空气CO水平。

Nicotine polacrilex (chewing gum) has been under investigation as a replacement for tobacco-delivered nicotine and also as a convenient drug administration modality which provides a model of more general interest for drug dependence researchers. Effective implementation of nicotine replacement strategies in clinical settings has required the conduct of basic research to evaluate various parameters such as dosing and measurement of dependence. During the past year we examined the time course of absorption of nicotine in the oral mucosa following nicotine polacrilex (gum) use in a second study we assessed. Preliminary analyses of the oral kinetics study suggest that substantial levels of nicotine absorption via the oral mucosa occur within 30 seconds of chewing. Preliminary analyses of the study of possible ethnic differences suggest that persons who are intolerant to milk (i.e., many persons of African and Asian heritage) yield elevated expired air CO levels.