EVENT-RELATED POTENTIAL STUDIES OF NORMAL AND ABNORMAL COGNITIVE PROCESSING

采用事件相关脑电位（ERP）研究认知功能 过程，如短期和长期记忆，空间注意力， 视觉搜索、心理旋转、心算和语言 理解力 对正常受试者的ERP研究旨在揭示 认知的大脑机制 患者研究 神经系统疾病是为了让我们更好地描述 病人的信息处理缺陷，同时提供信息， 这些认知过程背后的生理机制。 数据 收集完成的ERP研究痴呆症（阿尔茨海默氏症和 帕金森病、艾滋病和进行性核上性麻痹 （PSP）。 艾滋病毒和PSP研究的结果表明， 皮质下疾病的早期阶段，在皮质水平上处理， (i.e.,类似于皮质性痴呆）。这种模式逆转， 皮质下疾病进展。 关于模式的后续研究 PSP患者缺陷的特异性已经完成。 研究 作为注意过程的基础和影响注意过程的机制 数据分析在两项研究中完成，一项是关于正常对照 在空间数组中搜索以前短期存储的项目， 记忆力，以及疲劳对患者注意力的影响 慢性疲劳综合征（CFS）和正常对照组。 研究与博士。 丹尼尔·鲁奇金已经证明了记忆排练过程是 以大的负慢波为标志，不同的大脑区域 被调用来进行口头和空间短期记忆排练 流程. 关于短期和长期不稳定性的进一步研究 健忘症患者和多发性硬化症患者的记忆缺陷 已经完成，数据分析已经开始。 数据分析继续进行 颞叶切除术患者、Turner患者和 认知过程的成熟。 沃尔夫冈·米尔特纳博士的研究 旨在提供关于神经发生器的更多数据 认知过程的潜在机制 患者和对照数据具有 被用来验证约翰逊的变量模型的预测 控制P300振幅。 这些数据显示，与 广泛接受的概念，P300是一个组件，其幅度 代表了同时利用一些认知 处理“模块。“在对照组和 患者，这些模块似乎表明存在和功能 不同的记忆系统。

Event-related brain potentials (ERP) were used to study cognitive processes such as short- and long-term memory, spatial attention and visual search, mental rotation, mental arithmetic, and language comprehension. ERP studies of normal subjects were intended to reveal the brain mechanisms underlying cognition. Studies of patients with neurologic disorders were intended to allow us to characterize better patients' information processing deficits while providing information on the physiologic mechanisms underlying these cognitive processes. Data collection was completed in ERP studies of dementia (Alzheimer's and Parkinson's diseases, HIV disease, and progressive supranuclear palsy (PSP). The results from the HIV and PSP studies indicate that, in the earliest stages of subcortical disease, processing at the cortical level, (i.e., resembling a cortical dementia). This pattern reverses as the subcortical disease progresses. A follow-up study on the modality specificity of deficits in PSP patients has been completed. Studies of the mechanisms underlying and affecting attentional processes continue and data analysis is complete in two studies, one on how normal controls visually search a spatial array for items previously stored in short-term memory, and one on the effects of fatigue on attention in patients with chronic fatigue syndrome (CFS) and normal controls. Studies with Dr. Daniel Ruchkin have demonstrated that memory rehearsal processes are marked by large negative slow waves and that different brain areas are invoked to perform verbal and spatial short-term memory rehearsal processes. Additional studies on the nature of short- and long-term memory deficits in amnestic patients and multiple sclerosis patients have been completed and data analysis has begun. Data analysis continues on studies of temporal lobectomy patients, Turner's patients, and the maturation of cognitive processes. Studies with Dr. Wolfgang Miltner have been aimed at providing additional data on the neural generator mechanisms underlying cognitive processes. Patient and control data have been used to validate the predictions of Johnson's model of the variables controlling P300 amplitude. These data revealed that, contrary to the widely accepted notion, the P300 is a component whose amplitude represents the simultaneous utilization of a number of cognitive processing "modules." During recognition memory in controls and patients, these modules appear to indicate the presence and functioning of different memory systems.