GROWTH AND DIFFERENTIATION FACTORS IN BONE AND CARTILAGE

该项目的目标是调查增长的作用， 骨和软骨发育和修复中的分化因子。 特别强调骨发育的起始因子。 成骨蛋白（骨形态发生蛋白-3）是这种骨形成的原型。 分化起始因子 目前正在进行的项目 具有显著发现的研究是：1）软骨的表达 表型的成骨素; 2）刺激鸡肢芽细胞诱导 重组人骨诱导软骨分化及基质合成 形态发生蛋白-2B; 3）成骨素对软骨细胞的影响; 4） 胰岛素样生长因子II受体在软骨内分泌中的表达 骨分化; 5）通过化学方法鉴定受体 重组骨形态发生蛋白与成骨细胞的交联 细胞; 6）成骨蛋白对单核细胞具有趋化性，7） 灵长类动物头盖骨的巨大缺陷。 上述调查对纠正 颅面和牙周缺损与骨不连 手术

The objective of the project is to investigate the role of growth and differentiation factors in bone and cartilage development and repair. Special emphasis is placed on initiation factors in bone development. Osteogenin (Bone Morphogenetic Protein-3) is a prototype of such a differentiation initiation factor. The projects currently under investigation with salient findings are: 1) expression of cartilage phenotype by osteogenin; 2) stimulation of chick limb bud cell-induced cartilage differentiation and matrix synthesis by recombinant human Bone Morphogenetic Protein-2B; 3) influence of osteogenin on chondrocytes; 4) expression of insulin-like growth factor II receptor during endochondral bone differentiation; 5) identification of receptors by chemical crosslinking of recombinant bone morphogenetic protein to osteoblastic cells; 6) osteogenin is chemotactic for monocytes, and 7) repair of massive calvarial defects in primates. The above investigations have direct implications for correction of craniofacial and periodontal defects and non-unions in orthopaedic surgery.