CORE GRANT FOR VISION RESEARCH

由37名视觉科学家组成的小组申请了资金，以支持 四个研究模块，将提供一种机制来促进 并加强各种视觉科学家之间的互动 在眼科研究所的代表学科。这个 模块将扩展个人研究的研究努力 通过为以下领域的项目提供协作机会 哪些调查人员没有专业知识、资金或技术 能力。 这四个模块是：形态学、组织培养/克隆 抗体、动物资源和实验室计算机 申请。形态模块将提供光线和 电子显微镜能力，从而增加了 生物化学家可利用的形态技术， 药剂学家和免疫学家需要相关的 为他们的研究提供了形态数据。组织 培养/单抗模块将帮助PI选择 适宜的组织培养技术和培养基及生产中 特色化的眼部组织培养，并将 负责指定克隆的细胞融合和存储 产生单抗。这样的资源将增加 主要专长的调查人员的研究取决于其他 技术。动物资源模块将提供专业知识 在动物外科技术和术后方面提供帮助 护理、麻醉管理、药物管理和 所需的药物、抗原注射和出血 多克隆抗体的产生。实验室计算机 应用程序模块将为个人和 通过协助对接 具有实验室设备的微型计算机和通过开发 用于采集、处理和分析实验的软件 由微型计算机系统提供的数据。 这些单元将配备受过专门培训的人员 在各自的字段中。每个模块都将在立即 有监管经验的知名侦查员(S) 在那个区域。模块负责人将构成核心补助金 管理委员会，该委员会将负责 由高级调查人员委员会组成，由 ERI的研究单位。

Funds are requested by a group of 37 vision scientists to support four research modules that will provide a mechanism to facilitate and enhance interaction among the vision scientists in the various disciplines represented at the Eye Research Institute. The modules will extend research endeavors of individual research programs by providing collaborative opportunities for projects in which investigators do not have expertise, funding, or technical capabilities. The four module are: Morphology, Tissue Culture/Monoclonal Antibody, Animal Resource, and Laboratory Computer Applications. The Morphology Module will provide light and electron microscopy capabilities, thereby increasing the availability of morphological techniques to biochemists, pharmacologists, and immunologists who need correlative morphologic data for their research. The Tissue Culture/Monoclonal Antibody Module will assist PIs in selecting appropriate tissue culture techniques and media and in producing characterized tissue cultures of ocular origin, and will be responsible for cell fusions and storage of designated clones for monoclonal antibody production. Such a resource will augment the research of investigators who primary expertise lies in other technologies. The Animal Resource Module will provide expertise and assistance in animal surgical techniques and postoperative care, anesthesia administration, administration of drugs and medications, and antigen injections and bleedings required for polyclonal antibody production. The Laboratory Computer Applications Module will provide support to individual and collaborative efforts by assisting in the interfacing of microcomputers with laboratory equipment and by developing software for gathering, processing, and analyzing experimental data by microcomputer systems. The modules will be staffed by personnel with specialized training in the respective fields. Each module will be under the immediate supervision of a well-established investigator(s) have experience in that area. The module heads will constitute the Core Grant administrative committee, which will in turn be responsible for a committee of senior investigators comprising heads of the research units of ERI.