POST-ISCHEMIC ACCUMULATION OF CALCIUM IN BRAIN TISSUE

钙的分布和时间序列的观察 单次和重复缺血损伤后的累积， 45钙放射自显影显示， 单次和多次闭塞之间的钙吸收。一个引人注目 反复缺血时钙积聚的特点是大量摄取 Ca + +在丘脑，纹状体，后来，在内侧膝状体和 黑质此外，一个惊人的发现是， CAl时，锥体神经元几乎被破坏。我们的观察 这表明钙异常积聚可能是由于其他原因 而不是直接的缺血性损伤， 不可逆的神经元损伤

Observations on the distribution and the time sequences of calcium accumulation following single and repetitive ischemic insults using 45calcium autoradiography revealed significant differences in the pattern of calcium uptake between single and repeated occlusions. A striking feature of calcium accumulation in repeated ischemia was intense uptake of Ca + + in thalamus, striatum and, later, in the medial geniculate and substantia nigra. Also, a striking finding was an intense Ca + + uptake in CAl when the pyramidal neurons were virtually destroyed. Our observations suggest that abnormal accumulation of calcium may be due to other causes than a direct ischemic injury and may not necessarily indicate irreversible neuronal damage.