STUDIES OF THE NATURAL HISTORY AND TREATMENT OF DUCK HEPATITIS B VIRUS INFECTION

人类在结构和性质上有许多相似之处 乙肝病毒(乙肝病毒)和鸭乙型肝炎病毒(D乙肝病毒)。这些 相似之处表明，鸭子感染D乙肝病毒可能是一种有用的 人类乙肝病毒感染的实验模型，特别是由于乙肝病毒不能 在细胞培养中容易生长。出生时感染D乙肝病毒的鸭子变得 病毒的慢性携带者，尽管他们可能不会显性发展 肝炎。据报道，一些感染了登革热病毒的鸭子 肝细胞癌。与人类相似的肿瘤有很强的联系 病因学上与慢性乙肝感染有关。作为一种筛选测试 治疗慢性乙型病毒性肝炎的新有效疗法，新的抗病毒药物 免疫调节剂正在接受评估，因为它们有能力 抑制鸭乙肝病毒复制。2‘，3’-二脱氧肌苷和 2‘，3’-二脱氧鸟苷已被证明是有效的DHBs抑制剂 并且在鸭子身上几乎不会产生副作用。

There are many similarities in structure and properties between the human hepatitis B virus (HBV) and the duck hepatitis B virus (DHBV). These similarities suggest that DHBV infection in ducks may be a useful experimental model of human HBV infection, particularly as HBV cannot be grown readily in cell culture. Ducks infected with DHBV at birth become chronic carriers of the virus, although they may not develop overt hepatitis. Some DHBV-infected ducks have been reported to develop hepatocellular carcinoma. The analogous human tumor is strongly linked etiologically with chronic hepatitis B infection. As a screening test for new effective therapies for chronic type B hepatitis in man, new antiviral and immunomodulatory agents are being assessed for their ability to suppress DHBV replication in ducks. Both 2',3'- dideoxyinosine and 2',3'-dideoxyguanosine have been shown to be potent inhibitors DHBV replication and to produce few side effects in ducks.