RESPONSE OF MAMMALIAN CELLS TO CHEMOTHERAPY DRUGS

几种已证实有效的化疗药物，例如， 安东林、博莱霉素和贵金属衍生品 学习。细胞的解毒机制、修饰 细胞内氧化还原的生化调控反应 敏感和耐药细胞的状态和氧代谢 都是有意义的。产生的有害物种 抗肿瘤药物和对这些物种的细胞反应，如 以及硫醇化合物，以及它们与 这些药物和由这些药物产生的不稳定物种正在 检查过了。已经证明，细胞的枯竭 谷胱甘肽(GSH)合成抑制剂致敏细胞 对阿霉素和博莱霉素，而GSH升高提供 保护。最近，我们已经证明GSH的调制 对新卡宾抑素的生物活性有深远的影响。 将细胞从化疗中解救出来 学习。最近这些物质的运输机制 合成救援剂以及这种运输如何受到 细胞内谷胱甘肽或谷胱甘肽合成水平 抑制作用正在研究中。

Several chemotherapy agents with proven utility, e.g., Anthracylines, Bleomycins, and noble metal derivatives are being studied. The detoxification mechanisms, modification of cellular response by biochemical manipulation of intracellular redox status, and oxygen metabolism, in sensitive and resistant cells are of interest. Deleterious species produced by the antineoplastic drugs and cellular response to these species, as well as thiol compounds, and their metabolic interactions with the drugs, and labile species produced by the drugs are being examined. It has been demonstrated that depletion of cellular glutathione (GSH) by inhibitors of GSH synthesis sensitize cells to Adriamycin and Bleomycin while GSH elevation provides protection. Recently, we have shown that modulation of GSH has a profound effect on Neocarzinostatin biologic activity. Rescue of cells from chemotherapeutic treatment is being studied. The mechanism of transport of these recently synthesized rescue agents and how such transport is subject to intracellular levels of glutathione or glutathione synthesis inhibition is being studied.