MODELING OF TIME-DOSE RESPONSE OF HUMAN TUMORS AND NORMAL TISSUES

体外射束治疗通常在多个疗程中进行， 分散在几周内。 虽然某些规则， 分次次数、总时间和每次分次剂量 经过几十年的临床经验， 这些规则不被理解。 本项目试图 发展一个简单的数学描述的时间进程， 正常组织和肿瘤的反应，作为 这些变量。 正常组织的限制因素是它的短- 长期和长期最低可接受功能。 的 后者被认为是由之间的平衡决定的 功能细胞的磨损和 由残余的活干细胞产生的替代细胞， 那里的居民对辐射高度敏感 局部肿瘤治愈 需要让肿瘤中的所有克隆细胞都失去能力

External beam therapy is generally given over many sessions, spread-out over several weeks. Although certain rules as to number of fractions, total time, and dose per fraction have evolved empirically over several decades of clinical experience, these rules are ill-understood. The present project attempts to develop a simple mathematical description of the time course of the reactions of both normal tissue and tumor, as a function of these variables. The limiting factor for normal tissue is its short- term and long-term minimum acceptable functionality. The latter is assumed to be determined by the balance between attrition of the functioning cells and the production of replacement cells generated by the residual viable stem cells, whose population is highly radiation sensitive. Local tumor cure requires incapacitating every clonogenic cell in the tumor.