IRON-57 AND H-2 NUCLEAR MAGNETIC RESONANCE--NEW TOOLS

我们正在开发铁-57和氘的核磁共振 (核磁共振)作为生物医学科学中使用的一种实验方法。 在血液中发现的许多化合物含有铁核。其中包括 是细胞色素、血红蛋白或铁还蛋白。很少有化学物质 这些方法可以用来直接研究中心金属原子 这些蛋白质的环境。铁-57核磁共振正在被开发用于 那就是目的。 一段时间前，我们报道了铁-57核磁共振在研究中的应用 相关铁化合物的驰豫时间和化学位移 到生物实体。我们就这样确定了基本参数 为进一步研究铁的核磁共振所需。 我们目前开发这种方法的努力涉及到合成 一系列弱磁性铁-57富集物。努力 以观察金属共振正在进行中。

We are developing iron-57 and deuterium Nuclear Magnetic Resonance (NMR) as an experimental method for use in the Biomedical Sciences. Many compounds found in the blood contain iron cores. Among these are the cytochromes, hemoglobin, or ferridoxin. Few chemical methods may be used to directly study the central metal atom environments of these proteins. Iron-57 NMR is being developed for that purpose. Some time ago, we reported the utility of iron-57 NMR for study of relaxation times and chemical shifts of some iron compounds related to biological entities. We determined thus the basic parameters needed for further study of iron NMR. Our current efforts to develop the method have involved synthesis of series of weakly magnetic iron-57 enriched compounds. Efforts to observe the metal resonance are underway.