RENAL BIOPSY PATHOLOGY IN SYSTEMIC LUPUS ERYTHEMATOSUS

不同类型狼疮的发病机制 肾炎正在调查中。肾脏的详细分析 活组织病理检查正在对来自以下患者的样本进行 系统性红斑狼疮。活组织检查按主要疾病分类 狼疮性肾炎的类别，以及在 半定量标尺用于特定的组织学改变 活动度和慢性硬化性特征。这个 免疫复合体沉积模式与淋巴样细胞相互作用 肾单位的不同节段正在接受调查 免疫组织学技术和电子显微镜。形态测量学 正在开发技术来更准确地分析 狼疮性肾炎病程中肾脏的病理变化。 这些方法促进了对以下影响的分析 各种类型的免疫抑制剂被用来阻止 狼疮性肾炎的进展和他们将加强我们的 了解这种疾病的发病机制。

The pathogenetic mechanisms underlying the different forms of lupus nephritis are being investigated. Detailed analysis of renal biopsy pathology is being conducted on specimens from patients with systemic lupus erythematosus. Biopsies are classified by major category of lupus nephritis, as well as scored on a semiquantitative scale for specific histologic changes indicating the degree of activity and of chronic sclerosing features. The patterns of immune complex deposition and lymphoid cell interaction with different segments of the nephron are being investigated by immunohistologic techniques and electron microscopy. Morphometric techniques are being developed to analyze more precisely the changes in renal pathology during the course of lupus nephritis. These approaches have facilitated the analysis of the effects of various types of immunosuppressive agents used to halt the progression of lupus nephritis and they will enhance our understanding of the pathogenesis of this disease.