STUDY OF THE EFFECTS OF LIGHT AND TRIAZOLAM ON DELAYED SLEEP PHASE SYNDROME

睡眠时相延迟综合征（DSPS）的特征是慢性睡眠障碍。 晚上无法入睡，醒来时精神焕发 一大早 这些病人有一个异常延迟的 睡眠时间表，尽管正常的睡眠结构。 的目标 本研究旨在探讨治疗DSPS的可能性， 控制明暗循环 患者被纳入 在临床筛查和多导睡眠图的基础上制定方案。 治疗涉及两种明暗对照的交叉研究。 方案：1）2周的强光（全光谱，2500勒克斯） 从早上7：00到9：00，从下午4：00到 天黑 和2）从上午7：00开始2周的昏暗光（300勒克斯）。 从早上9点到晚上4点到傍晚都戴着透明的护目镜 的 9名患者在这两种条件下治疗，明亮的光暗 护目镜条件已被证明上级对照治疗，因为 通过自我报告和早晨睡眠潜伏期研究进行测量。 几 的患者选择继续接受强光治疗 在正式议定书结束后。 这些发现 这表明，明智的定时明亮和黑暗的曝光， 有效推进DSPS患者的昼夜节律周期。

Delayed sleep phase syndrome (DSPS) is characterized by a chronic inability to fall asleep in the evening and to wake up refreshed early in the morning. These patients have an abnormally delayed sleep schedule in spite of normal sleep architecture. The goal of this study is to investigate the possibility of treating DSPS by manipulating the light-dark cycle. Patients were included in the protocol on the basis of clinical screening and polysomnography. The treatment involved a crossover study between two light-dark regimens: 1) 2 weeks of bright light (full spectrum, 2500 lux) from 7:00 a.m. to 9:00 a.m. and dark goggles from 4:00 p.m. to nightfall. and 2) 2 weeks of dim light (300 lux) from 7:00 a.m. to 9:00 a.m. and clear goggles from 4:00 p.m. to nightfall. Of nine patients treated under both conditions, the bright light-dark goggle condition has proven superior to the control treatment, as measured by self-report and morning sleep latency studies. Several of these patients have chosen to continue bright light treatment after the conclusion of the formal protocol. These findings suggest that judiciously timed bright and dark exposures are effective in advancing the circadian cycle of patients with DSPS.