MATERNAL INFECTION STUDY

围产期合作项目（CPP）数据分析 在产妇感染方面继续存在。 (The CPP是一种 对大约60，000名孕妇进行的前瞻性研究，以及以下内容- （在孩子的第七个年头）。 两 主要方法已被使用，一个前瞻性和一个案例 控制方法。 自从血清学证实所有的 所有妇女在怀孕期间发生的常见感染， 项目本来就不可行，病例对照设计 已实施评估11种抗原在女性中的滴度 异常儿童，与匹配的对照妇女相比， 正常儿童 这项研究没有显示出任何明显的关联 在怀孕的第二个和第三个三个月之间 怀孕和对孩子的特殊伤害。 一项前瞻性研究 儿童发病率与母体抗体之间的关系 孕妇人群中弓形虫病的发病率水平一直是 完成 弓形虫病的前瞻性血清学研究， 根据研究中的前23,000例怀孕， 耳聋、小头畸形和低智商的风险增加， 母源抗体高的妇女所生的子女 弓形虫病 报告结果的手稿 弓形虫病研究已被接受发表， 已提交血清学确诊感染的研究报告， 出版物

Analysis of the Collaborative Perinatal Project (CPP) data continues in the area of maternal infection. (The CPP is a prospective study of approximately 60,000 gravidae and the follow- up of their children through the seventh year of life.) Two primary methodologies have been used, a prospective and a case control approach. Since serological confirmation of all of the common infections occurring during pregnancy on all women in the project would not have been feasible, a case control design has been implemented assessing the titer of 11 antigens in women with abnormal children, in comparison with matched control women with normal children. This study did not show any clear association between infection during the second and third trimester of pregnancy and specific damage to the child. A prospective study of the association of childhood morbidity with maternal antibody level to toxoplasmosis in a population of pregnant women has been completed. The prospective serological study of toxo-plasmosis, based on the first 23,000 pregnancies in the study, has shown increases in the risk of deafness, microcephaly, and low IQ among children born to women with high maternal antibody to toxoplasmosis. The manuscript reporting the results of the toxoplasmosis study has been accepted for publication, and the study of serologically confirmed infections has been submitted for publication.