DEVELOPMENT OF BIOCALORIMETERS FOR SOLUTION AND CELL BIOCHEMICAL STUDIES

一种新型全钽止流器的研制 微量热计已经进行到一个完整的一套点， 的测试数据已经运行，仪器现在可以运行了。 一些DNA药物结合的实验正在进行中 反应. 这项工作是与科学家合作完成的 在罗格斯大学 每种试剂只有80微升 需要的反应。 其灵敏度是 批量量热计，每种试剂需要1ml。 用于反应 由于半衰期快于0.1秒，每3分钟就可以进行一次反应， 分钟 仪器由微机控制， 获取数据并进行在线分析。 广泛的工作与 血红蛋白计划在明年与 NIA、LAIR和约翰霍普金斯大学的科学家。

The development of a new all tantalum stopped flow microcalorimeter has proceeded to the point that a complete set of test data have been run the instrument is now operational. Experiments are in progress on a number of DNA drug binding reactions. This wok is being done in collaboration with scientists at Rutgers University. Only 80 microliters of each reagent are needed per reaction. The sensitivity is ten times that of the batch calorimeter requiring 1 ml of each reagent. For reactions with halflives faster than 0.1 second, a reaction can run every 3 minutes. The instrument is controlled by a microcomputer which takes the data and analyzes it on line. Extensive work with hemoglobin is planned for the coming year in collaboration with scientists at NIA, LAIR and Johns Hopkins University.