INSULIN SUBSTRATE AND ENERGY METABOLISM OF LUNG CANCER PATIENTS

肉瘤患者在临床前表现出代谢异常 恶病质的证据，一种复杂的综合征，包括组织 消瘦、厌食、乏力。 啮齿动物实验室研究 表明外源性胰岛素治疗可以通过以下方式逆转恶病质： 改善对化疗的反应，增加瘦体重， 提高手术存活率。 本研究将调查 胰岛素治疗将有益于恶病质的人。 先前的工作已经 不包括肺癌患者;相反，它集中在 肉瘤患者。 胰岛素治疗前后的胰岛素需求 癌症治疗将被确定，并与年龄，性别， 体重匹配的志愿者 静息能量消耗和 还将测量患者的前臂基质通量， 匹配志愿者

Sarcoma patients exhibit metabolic abnormalities before clinical evidence of cachexia, a complex syndrome that includes tissue wasting, anorexia and asthenia. Laboratory studies of rodents indicate exogenous insulin therapy can reverse cachexia by improving response to chemotherapy, increasing lean mass and increasing surgical survival. This study will investigate whether insulin therapy will benefit cachectic humans. Previous work has not included lung cancer patients; rather, it concentrated on sarcoma patients. Insulin requirements before and after anti- cancer treatment will be determined and compared to age, sex and weight matched volunteers. Resting energy expenditure and forearm flux of substrates will also be measured for patients and matched volunteers.