STUDIES OF THE IMMUNOLOGIC RESPONSES TO NON-FILARIAL HELMINTH INFECTIONS

美国钩虫(Necator Americanus)实验感染 普通志愿者，目标是定义渐进式变化 对蠕虫感染的免疫学反应(尤其是IgE)。它被发现了 小剂量的50条丝状幼虫就能 产生显著的一过性胃肠道症状和明显的血液 嗜酸性粒细胞增多，但可诱导其他T细胞和B细胞依赖的免疫反应 震级如此之低，以至于很难评估 广泛地。嗜酸性粒细胞结构和功能的明显变化 可以在感染过程中记录个人资料。这个 低密度的嗜酸性粒细胞比例增加了两到三倍 感染时产生超氧化物和迁移的能力 对趋化的刺激也明显增加。这些变化是 仅见于嗜酸性粒细胞，在中性粒细胞中未见 人口。

Experimental hookworm (Necator americanus) infections were induced in normal volunteers with a goal toward defining progressive changes in immunologic responses (especially IgE) to helminth infection. It was found that a small infecting dose of 50 filariform larvae was capable of producing significant transient gastrointestinal morbidity and marked blood eosinophilia but induced other T-cell and B-cell dependent immune responses that were of such low magnitude as to be difficult to evaluate extensively. Clear changes in eosinophil structural and functional profiles could be documented during the course of the infections. The proportion of 'hypodense' eosinophils increased two- to three-fold during infection while the capabilities of generating superoxide and of migrating to a chemotactic stimulus also increased significantly. Such changes were limited to eosinophils and were not seen in the neutrophil granulocyte population.