THE POPULATION GENETICS OF TRANSPOSABLE ELEMENTS

自然选择对个体有害影响的作用 通过比较转座因子插入的数量， X染色体上的转座因子与 果蝇 几乎没有证据表明选择反对copia样 X染色体上的元素。 这表明了其他可能的机制 (e.g.染色体重排）可能在去除 转座因子。 第二项研究调查了拷贝数进化的理论 在远系繁殖群体中调节转座因子。 的 这项研究的预测是，显性效应，如染色体 重新安排，很可能是最终使 复制数量调控的进化可能。 最后， 在着丝粒和端粒区域减少重组的进化， 发展和相关的积累串联重复的DNA， 研究了

The role of natural selection against the deleterious effects of individual transposable element insertions was investigated by comparing the numbers of transposable elements on the X chromosomes versus autosomes of Drosophila. There is little evidence for selection against copia-like elements on the X chromosomes. This suggests other possible mechanisms (e.g. chromosome rearrangement) are likely to be important in removing transposable elements from natural populations. A second study investigated the theory of the evolution of copy number regulation of a transposable element in an outbreeding population. The prediction of this study is that dominant effects, such as chromosome rearrangements, are likely to be the events that ultimately make the evolution of copy number regulation likely. Finally, the theory of the evolution of reduced recombination in centromeric and telomeric regions was developed and the associated accumulation of tandemly repeated DNA was investigated.