INVOLVEMENT OF CALCIUM, FODRIN, AND GLUTAMATE IN SEIZURES

这项工作将涉及癫痫灶的研究和对 谷氨酸受体、细胞骨架蛋白及其通量的研究现状 钙离子。癫痫发作已被证明是一种 细胞外钙离子向细胞内部迁移的结果。 因为已知钙离子也能激活钙蛋白，而钙蛋白会降解 Fodrin，并负责维护膜的完整性。 这项研究中感兴趣的问题是确定 精神崩溃与癫痫活动的扩散直接相关。 此外，从难治性癫痫患者获得的癫痫灶 癫痫发作将进行氨基酸、儿茶酚胺异常筛查 以及神经肽水平。

The work will involve the study of epileptic foci and the evaluation of the status of glutamate receptors, the cytoskeletal protein fodrin and the flux of calcium ions. The epileptic seizure has been demonstrated to occur as a result of a shift of external calcium ions to the interior of the cell. Since calcium ions are also known to activate calpain, which degrades fodrin, and is responsible for maintaining the integrity of the membrane. The question of interest in this study is to determine whether fodrin breakdown is directly linked to the spread of epileptic activity. In addition, the epileptic focus obtained from patients with intractable seizures will be screened for abnormalities in amino acid, catecholamine and neuropeptide levels.