CELL MEDIATED CYTOTOXICITY

广泛反应的抗肿瘤细胞毒细胞反应，体外产生 用淋巴因子IL2培养的小鼠脾细胞在 通过将多肌苷酸(Poly I)添加到 文化。虽然Poly I是一种人工合成的多核苷酸、大分子 多阴离子碳水化合物，其中一些天然存在于人类中，一直是 鉴定了哪些像Poly I.小鼠品系的研究 在Poly I的作用下，脾细胞只产生低水平的抗肿瘤细胞毒性， 表明抑制细胞间的相互作用是导致低血压的原因 回应。

Broadly reactive antitumor cytotoxic cell responses, generated in vitro by mouse splenocytes cultured with the lymphokine IL2, are modulated in a strain-dependent fashion by addition of polyinosinic acid (Poly I) to the cultures. Although Poly I is a synthetic polynucleotide, macromolecular polyanionic carbohydrates, some of which occur naturally in man, have been identified which act like Poly I. Studies of mouse strains whose splenocytes generate only low levels of antitumor cytotoxicity with Poly I, show that suppressive cell-cell interactions contribute to the low responses.