EPIDEMIOLOGIC STUDIES OF DIET AND CANCER HAWAII

该项目资助的主题是关于饮食的流行病学研究 和癌症在夏威夷的多民族人口中的比例。 它汇集了两个 我们目前研究的方面：饮食在癌症中的作用研究 病因学和流行病学研究中的饮食方法学研究。 提出了七个独立但相互关联的项目。 其中四个是 癌症的病因学研究（包括结肠癌，乳腺癌，甲状腺癌，肺癌， 膀胱和其他）与特定食物的饮食接触的关系， 它们的营养成分（如脂肪、胆固醇和维生素）。 这些 四项研究涉及队列和病例对照方法， 我们早期的横断面和病例对照研究的结果。 数据 收集主要涉及个人采访和监视， 虽然生物标本也将收集在其中一个 问题研究 另外三项研究考察了饮食史的不同方面 方法，包括其有效性，重现性和等效性 不同的方法来量化饮食摄入量。 所有7个项目 造成专业和技术人员大量重叠， 以及在核心支撑部件的使用中。 这个研究项目 不仅应该推进我们对饮食因素在 癌症的病因，而且还导致更好的饮食史数据 为今后的流行病学研究提供收集方法。

This Program Project Grant has as its theme epidemiologic research on diet and cancer in the multiethnic population of Hawaii. It brings together two aspects of our current research: studies on the role of diet in cancer etiology, and studies of dietary methodology in epidemiologic research. Seven separate but interrelated projects and proposed. Four of these are etiologic studies of cancer (including colon, breast, thyroid, lung, bladder and others) in relation to dietary exposures to specific foods and their nutrient components (such as fats, cholesterol and vitamins). These four studies involve both cohort and case-control approaches, and build on the results of our earlier cross-sectional and case-control studies. Data collection primarily involves personal interviews and surveillance, although biological specimens will also be collected in one of the studies. Three other studies examine different aspects of the diet history method, including its validity, its reproducibility, and the equivalence of different methods for quantifying dietary intakes. All seven projects entail considerable overlap in professional and technical personnel, as well as in the use of core support components. This research program should not only advance our knowledge about the role of dietary factors in the etiology of cancer, but also lead to better dietary history data collection methods for future epidemiological studies.