课题基金 / 基金详情

PROGRAM IN RETROVIRUSES AND CANCER

PROGRAM IN RETROVIRUSES AND CANCER
逆转录病毒和癌症项目
批准号:
3093218
负责人:
PAUL Eric NEIMAN
金额:
$55.88万
依托单位国家:
美国
项目类别:
财政年份:
1980
资助国家:
美国
项目状态:
已结题
起止时间:
1980-07-01 至 1986-09-29

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中文摘要
翻译
这项资助是关于逆转录病毒在恶性疾病中的作用。 宿主细胞的转化。个别项目将解决 整合白血病病毒基因组和内源性宿主的特征 与禽流感病毒转化基因相关的细胞序列(内源性onc) 白血病病毒。病毒RNA和蛋白质基因产物的特性 以及在两只小鼠体内释放的病毒的生物学特征 白血病病毒诱导的胸腺瘤和禽白血病病毒诱导的法氏囊 淋巴瘤。方法将包括病毒和宿主细胞的分子克隆 序列和使用杂交瘤来产生单抗。这个 后者将用于病毒和宿主核蛋白的研究。
英文摘要
This grant is concerned with the role of retroviruses in malignant transformation of host cells. Individual projects will address the characterization of integrated leukemia virus genomes and of endogenous host cell sequences (endogenous onc) related to the transforming genes of avian acute leukemia viruses. The characterization of viral RNA and protein gene products as well as a biological characterization of released viruses in both murine leukemia virus-induced thymomas and avian leukemia virus-induced bursal lymphomas. Methods will include molecular cloning of viral and host cell sequences and the use of hybridomas to generate monoclonal antibodies. The latter will be used in studies of both viral and host nuclear proteins.
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会议论文
Genomic Analysis of Gene Copy Number in Thyroid Cancer
Workshop On Experimental Models from Bursa of Fabricius
MOLECULAR CLONING OF C-MYC TRANSCRIPTION FACTOR GENES
GENES REGULATING APOPTOTIC CELL DEATH IN BURSAL B-CELLS
海外基金