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TCDD TERATOGENICITY--MODULATION IN MIXTURES

TCDD TERATOGENICITY--MODULATION IN MIXTURES
TCDD 致畸性——混合物中的调节
批准号：
4693189
负责人：
L S BIRNBAUM
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/4693189
关键词：
cleft palate cortisol dioxins drug adverse effect environmental toxicology halobiphenyl /halotriphenyl compound hydronephrosis polychlorodibenzofuran teratogens thyroxine toxicant interaction toxicant screening toxin metabolism

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中文摘要
翻译
TCDD（二恶英，2,3,7,8-四氯二苯并-对二恶英）是毒性最大的一种
英文摘要
TCDD (dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin) is one of the most toxic chemicals known to man. Progressive weight loss and thymic atrophy are two of its most frequent toxic symptoms. The induction of cleft palate and hydronephrosis characterize the teratogenic response of mice to TCDD. Because of the sensitivity of this response, we decided to use teratogenicity to measure the interaction of TCDD and other compounds with which it occurs in the environment. Such chemicals include polychlorinated dibenzofurans, polychlorinated biophenyls, hormones such as thyroxins and hydrocortisone, and drugs. The effects on TCDD toxicity are dependent upon chemical structure and may support a mechanistic hypothesis of TCDD toxicity.
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DISPOSITION OF HALOGENATED DIBENZOFURANS
DISPOSITION OF XENOBIOTICS
TCDD TERATOGENICITY--MODULATION IN MIXTURES
MECHANISM OF DIOXIN TOXICITY
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