MATERNAL INFECTION STUDY

围产期合作项目（CPP）数据的分析继续在 产妇感染的区域。 (The CPP是一项前瞻性研究， 约60 000名孕妇及其子女的后续行动， 生命的第七个年头）。 妊娠期母源性感染与妊娠结局的关系 怀孕后的孩子的地位正在检查使用这两个 母亲的临床和血清学确认感染。 两个主要的方法已被使用，前瞻性和病例对照 approach. 特定儿童结局风险的前瞻性评估 用于所有临床确认的感染。 由于血清学 确认怀孕期间发生的所有常见感染 项目中的所有女性都不可行， 已经实施了评估女性中11种抗原滴度的设计 异常儿童，与对照组妇女相比， 正常儿童 对特定感染的特殊研究，例如 尖锐湿疣和弓形虫病正在进行或已经完成， 滴度分布和频率的描述性研究 不同人种和孕妇年龄的各种抗原的血清转换， 已完成孕妇人口普查。 准 弓形虫病血清学研究及其与妊娠的关系 结果显示，基于研究中的前23，000例妊娠， 儿童耳聋、小头畸形和低智商的风险增加 母亲对弓形虫病的抗体很高

Analysis of the Collaborative Perinatal Project (CPP) data continues in the area of maternal infection. (The CPP is a prospective study of approximately 60,000 gravidae and the follow-up of their children through the seventh year of life.) The relationship of maternal infection during pregnancy with the later status of the child is being examined using both clinical and serologically-confirmed infections in the mother. Two primary methodologies have been used, a prospective and a case control approach. A prospective assessment of risk of specified childhood outcome was used for all clinically confirmed infections. Since serological confirmation of all of the common infections occurring during pregnancy on all women in the project would not have been feasible, a case control design has been implemented assessing the titer of 11 antigens in women with abnormal children, in comparison with matched control women with normal children. Special studies of specific infections such as condylomata and toxoplasmosis are in progress or have been completed and a descriptive study of the distribution of titers and frequency of seroconversions by race and age of gravidae for various antigens in a population of pregnant women has been completed. The prospective serological study of toxoplasmosis and its relationship with pregnancy outcome, based on the first 23,000 pregnancies in the study, has shown increases in the risk of deafness, microcephaly and low IQ among children born to women with high maternal antibody to toxoplasmosis.