Characterisation, determinants, mechanisms and consequences of the long-term effects of COVID-19: providing the evidence base for health care

我们将解决以下由患者定义的问题：什么是长冠状病毒？如何诊断？为什么我长covid ？covid - 19对我的健康、工作能力和家庭有什么影响？我康复的机会有多大？这项研究将如何确保我在长期covid期间得到正确的治疗和支持？C-19感染对身心健康造成的后果，被称为长冠状病毒，经常发生。我们对长期covid的了解，包括如何最好地诊断、风险因素、健康和经济后果，都很差，限制了帮助人们的努力。我们将结合使用全国匿名联系的初级保健电子健康记录，以及对全国各年龄段人群的纵向研究。我们向参与者询问了C-19感染、长期covid症状，并在大流行前多年收集了健康和社会经济信息。从这些研究中，我们将要求报告长期covid的人和比较组佩戴测量运动能力、呼吸和心率的腕带，并完成关于心理健康和认知功能的在线问卷。他们还将被邀请到诊所进行非侵入性成像，以检查大脑、肺和心脏等重要器官的潜在损伤。患者、监督电子健康记录研究的公众成员和研究成员都参与了研究问题的形成，并将在项目期间进行咨询。此外，长期covid患者及其家人将从研究中参与制定长期covid的诊断工具，并帮助我们了解康复的决定因素和对治疗的反应。我们将与参与指南的机构（NICE，也是这个项目的一部分）和政府（通过出版物）分享研究结果。

We will address the following patient defined questions: What is long-COVID and how is it diagnosed? Why have I got long-COVID? What effects will long-COVID have on my health, ability to work and family? What are my chances of recovery? How will this research ensure I am getting the right treatment and support for long-COVID? Physical and mental health consequences of C-19 infection, termed long-COVID, occur frequently. Our understanding of long-COVID, including how best to diagnose, risk factors, health and economic consequences, is poor, limiting efforts to help people. We will use a combination of national anonymised linked primary care electronic health records, and longitudinal studies of people of all ages across the country. We have asked participants about C-19 infections, long-COVID symptoms, and have collected health and socioeconomic information for many years before the pandemic. From these studies, we will ask people reporting long-COVID, and comparator groups, to wear a wrist band measuring exercise ability, breathing, and heart rate, and complete online questionnaires on mental health and cognitive function. They will also be invited to clinic for non-invasive imaging to look at potential damage to vital organs, such as the brain, lungs and heart. Patients, members of the public overseeing electronic health record research, and study members have been involved in shaping the research questions, and will be consulted for the duration of the project. In addition, people with long-COVID and their families, from the studies, will be involved in shaping the diagnostic tools for long-COVID, and aiding our understanding of determinants of recovery, and responses to therapy. We will share findings with bodies involved in guidelines (NICE, who are also part of this project), with government (via the publications).