STUDY OF THE CLINICAL COURSE, PATHOGENESIS AND TREATMENT OF SEPTIC SHOCK

脓毒性休克是一种由身体对 微生物或其有毒产物。感染性休克的发病率 一直在稳步增长。它的死亡率为40%到90%， 已成为重症监护病房的主要死亡原因， 美国的该综合征的病理生理学非常复杂; 一系列外源性毒素和内源性介质可能导致 在数小时至数天的时间内进行性多系统器官衰竭， 通过我们还不太了解的机制。在过去的12个 多年来，NIH感染性休克方案（82-CC-123）产生了重要的 对脓毒症的病理生理学、自然史和治疗的见解 冲击.根据该议定书，调查仍在继续， 儿科患者的心脏和外周血管表现 败血症（使用超声心动图和前臂血流测量）， 脓毒症的内源性和外源性介质的相互作用 （使用从脓毒症患者和非脓毒症对照中抽取的血液标本 患者），以及脓毒症相关的成人呼吸道感染的发病机制 窘迫综合征（使用支气管肺泡灌洗）。

Septic shock is a syndrome produced by the body's response to microorganisms or their toxic products. The incidence of septic shock has been increasing steadily. It carries a mortality of 40 to 90 percent and has become the leading cause of death in intensive care units in the United States. The pathophysiology of the syndrome is remarkably complex; an array of exogenous toxins and endogenous mediators may lead to progressive multi-system organ failure during a period of hours to days, through mechanisms that are still poorly understood. Over the past 12 years, the NIH Septic Shock Protocol (82-CC-123) has produced important insights into the pathophysiology, natural history, and therapy of septic shock. Under the protocol, investigations are continuing, in adult and pediatric patients, of the cardiac and peripheral vascular manifestations of sepsis (using echocardiography and measurement of forearm blood flow), the interplay of exogenous and endogenous mediators of the sepsis syndrome (using blood specimens drawn from septic patients and nonseptic control patients), and the pathogenesis of sepsis-related adult respiratory distress syndrome (using bronchoalveolar lavage).