UTILIZATION OF SPECIALIZED HARDWARE FOR DNA SEQUENCE ANALYSIS

DCRT正在提供应用生物系统公司的Inherit系统作为 提供给NIH内部研究社区的共享资源。这个系统 采用使用Apple Macintosh计算机的客户端/服务器架构 作为客户端平台。科学家可以购买Macintosh客户端 软件，并通过NIH网络访问Inherit系统。 为了加速结果，Inherit使用了高度专门化的硬件。这个 快速数据查找器(FDF)并行处理器可以执行并行模式 在大型数据库中以超过1500万次的速度匹配搜索 每秒字符数。这一速度允许在数小时内完成任务 这通常需要几天的时间来使用通用工作站。 该系统最适合于：(1)中到大型测序的组装 项目；(2)在基因和蛋白质数据库中搜索同源基因 基因序列；以及(3)快速搜索遗传基序，例如 监管要素。模式搜索语言并入到 系统允许构建非常复杂的查询。 该项目突出了NIH网络带来的潜力 通过桌面提供强大而复杂的计算资源 计算机连接到科学家的台式计算机。 Inherit是Perkin Elmer公司的商标。

DCRT is making available an Applied Biosystems, Inc. Inherit system as a shared resource to the NIH intramural research community. This system employs a client/server architecture using an Apple Macintosh computer as the client platform. Scientists can purchase Macintosh client software from ABI and access the Inherit system over the NIH network. To speed results, Inherit makes use of highly specialized hardware. The Fast Data Finder (FDF) parallel processor can perform parallel pattern matching searches through large databases at a rate of over 15 million characters per second. This speed permits completion in hours of tasks which often require days using general workstations. This system is best suited to: (1) assembly of medium to large sequencing projects; (2) searching the gene and protein databases for homologous gene sequences; and (3) rapid searches for genetic motifs such as regulatory elements. A pattern search language incorporated in the system permits construction of very complex queries. This project highlights the potential of the NIH network to bring powerful and sophisticated computational resources through the desktop computer to the scientist's benchtop. Inherit is a trademark of Perkin Elmer, Inc.