SOLID STATE INTRAOPERATIVE BETA CAMERA

本提案的目标是开发一种原型术中β相机（IOBC），专门设计用于成像β发射放射性药物（如18F， 124I，186Re和188Re）合并到大脑或其他器官（如乳腺，淋巴结，甲状腺等）的肿瘤。该探头用于术中手术环境。患者在手术前注射肿瘤寻找放射性药物，进行手术切除肿瘤块，然后使用IOBC探针对该部位进行成像以定位残余的亚临床肿瘤细胞。该系统旨在通过在不过度切除正常组织的情况下更完整地切除亚临床肿瘤细胞，从而显著提高肿瘤切除手术的成功率。术中β相机将使用一个小而轻，可拆卸的头部，包括一个1024像素的硅pin阵列，该阵列对β粒子高度敏感，但对嘈杂的伽马背景辐射不敏感。在第一阶段的可行性研究中，我们成功地构建了一个256像素的阵列原型，并在电子噪声、空间分辨率、灵敏度和对β发射器的响应均匀性方面对其性能进行了表征。该设备的性能与最初预期的一样好，甚至更好。第二阶段将设计和开发一套完整的术中成像系统，包括小型化探测器探头、处理电子设备、数据采集、图像处理和显示硬件和软件。该系统将在现实的临床条件下使用加州大学洛杉矶分校医学院的肿瘤幻影进行表征。建议的商业应用：需要商业术中成像相机来提高肿瘤切除手术的成功率。这可以显著缩短手术时间，相应降低手术成本，并导致更快的恢复和更低的恢复成本。提出的工作重点是一种具有可拆卸、紧凑和轻量级成像探头的新型半导体相机系统。不同版本的探针可以适用于乳房，淋巴结，甲状腺和其他器官。

The goal of this proposal is to develop a prototype intraoperative beta camera (IOBC) specifically designed for use in imaging beta emitting radiopharmaceuticals (such as 18F, 124I,186Re, and 188Re) incorporated into tumors in the brain or other organs such as breast, lymph nodes, thyroid and others. The probe is intended for use in the intraoperative surgical environment. The patient is injected with a tumor seeking radiopharmaceutical before surgery, the surgical procedure to remove tumor mass is performed, and the site is then imaged using the IOBC probe to locate residual subclinical tumor cells. The proposed system is intended to significantly improve the success of tumor removal surgeries by allowing more complete removal of subclinical tumor cells without excessive removal of normal tissue. The intraoperative beta camera will use a small and light-weight, detachable head comprising a 1024-pixel silicon-PIN array which is highly sensitive to beta particles but insensitive to the noisy gamma background radiation. During the Phase I feasibility study we successfully constructed a 256- pixel prototype of the array and characterized its performance in terms of electronic noise, spatial resolution, sensitivity, and uniformity of response to beta emitters. The device performed as well or better than was originally expected. In Phase II a complete intraoperative imaging system including miniaturized detector probe, processing electronics, data collection, image processing and display hardware and software will be designed and developed. The system will be characterized under realistic clinical conditions using tumor phantoms at the UCLA School of Medicine. PROPOSED COMMERCIAL APPLICATIONS: There is a need for commercial intraoperative imaging cameras to improve the success of tumor removal surgeries. This could significantly reduce time in surgery with a commensurate decrease in cost of surgery and leading to faster recovery and lower recovery cost. The proposed work is focused on a novel semiconductor beta camera system with detachable, compact, and lightweight imaging probe. Different versions of the probe could be adapted for breast, lymph nodes, thyroid, and other organs.