PROSPECTIVE STUDY OF CHILDREN OF SCHIZOPHRENIC PARENTS

这是纽约高中主要数据收集的最后阶段- 风险项目（NYHRP），一个多特质，多测量，前瞻性 研究中，两个独立的样本的后代， 精神分裂症、情感疾病和正常的父母都被跟踪 从7岁到12岁， 1971-72或77 - 79年最初的目标是尽早识别 精神分裂症的神经生物学预测因子这一目标已经扩大， 该领域已经发展到关注定义完整的 内表型和临床性状的表型互补 在精神分裂症的谱系上虽然我们会收集最新的 临床、环境和家族史数据，我们将 主要集中在评估和综合收集的数据 先前并整合变量的不同域（例如， 社会和神经行为的措施）在广泛的分析， 将需要解决的问题和假设中提出的， 纵向研究具体来说，我们将从我们广泛的 档案，积累的社会，环境和心理数据， 大约有350个后代，最近大约有160个 检查兄弟姐妹; 2）准备后代的寿命概况，使用 所有数据来源; 3）身体/心理的阵列家庭谱系 （包括轴I诊断和轴II特征） 父母、子女和二级亲属。我们将收集 其他数据：4）邮寄问卷，以获得“精神病- 5）最后一轴I， 与年轻样本（样本B）的II诊断访谈，以及 选择的样品A受试者; 6）血液样品以保存DNA并用于 用于评估热休克蛋白的血清抗体 (hsp（60）;（Z）继续每年与 后代更新自己的临床和治疗历史，以及 作为他们的家族病史我们还将：J8继续 为寻求援助的对象提供转介服务。最重要的是我们 将9）进行大量的数据分析，重点是：比较 特定性状作为遗传易感性指标的潜力， 精神分裂症和作为成年期精神疾病的预测因子; 这种分析将包括建立性状的综合指数 以及同胞对和其他系谱内比较的检查， 上述人口的家庭聚集和隔离估计数 性状

This is the final phase of major data collection in the New York High- Risk Project (NYHRP), a multi-trait, multi-measurement, prospective study, in which two independent samples of offspring of schizophrenic, affectively ill and normal parents have been followed with repeated testing and clinical evaluations since ages 7 to 12 in 1971-72 or '77-'79. The initial goal was to identify early neurobiological predictors of schizophrenia. This goal has expanded as the field has evolved to focus on the problem of defining the full phenotypic complement of endophenotypic and clinical traits making up the schizophrenia spectrum. Although we will collect updated clinical, environmental and family history data in this phase, we will concentrate chiefly on rating and synthesizing the data amassed previously and integrating the different domains of variables (e.g., social and neurobehavioral measures) in the extensive analyses that will be needed to resolve the questions and hypotheses posed in this longitudinal study. Specifically, we will 1) rate, from our extensive files, accumulated social, environmental and psychological data on the approximately 350 offspring and their approximately 160 recently examined siblings; 2) prepare lifetime profiles on the offspring, using all sources of data; 3) array family pedigrees of the physical/mental (including Axis l diagnoses and Axis Il features) health histories on the parents, offspring, and second-degree relatives. We will collect additional data with: 4) mailed questionnaires to obtain "psychosis- proneness" and schizotypy scales on the offspring; 5) final Axis I and II diagnostic interviews with the younger sample (Sample B) and selected Sample A subjects; 6) blood samples to preserve DNA and for use in an assessment of serum anti-bodies for the heat-shock protein (hsp 60); and Z) continued annual telephone interviews with the offspring to update their own clinical and treatment histories, as well as their family histories of disorders. We will also: J8 continue to offer referral services to subjects seeking assistance. Most of all, we will 9) conduct a large number of data analyses focused on: comparing the potential of specified traits as indicators of the genetic liability to schizophrenia and as predictors of adulthood psychiatric conditions; such analyses will include construction of composite indices of traits and examination of sib-pair and other intra-pedigree comparisons as estimates of familial aggregation and segregation of the aforementioned traits.