HIGH RESOLUTION EEG FOR POLYSOMNOGRAPHY

随着神经科学在理解人类大脑功能方面的新进展，需要改进的评估技术来表征睡眠的功能性神经生理学。脑血流成像的fMRI和PET方法在表征睡眠组织方面面临局限性，因为它们的测量技术（如头部固定和巨大的扫描噪声）对正常睡眠来说是有问题的。此外，睡眠神经生理学涉及许多必须用毫秒时间分辨率描述的快速事件。我们建议开发SOMNA（睡眠组织和神经唤醒的微观状态）评估系统的密集传感器阵列脑电图（EEG）的睡眠研究。128通道和256通道EEG的改进空间采样将纠正传统EEG的重要不足，有望对睡眠神经生理学进行更准确的解剖分析。SOMNA系统将提供睡眠EEG和多导睡眠图测量的先进计算机化评估，并且它将EEG分割成唤醒的微观状态以及传统的睡眠阶段。该系统将推进临床睡眠实验室的技术，为电流密度、电场动画和MR约束源定位的研究提供新的密集阵列EEG方法。对睡眠生理学的进一步了解可能对临床睡眠障碍（包括失眠、癫痫和睡眠呼吸暂停）具有重要意义。拟议的商业应用：使用SOMNA系统进行测试和解释的便利性不仅对睡眠研究中心具有吸引力，而且对临床睡眠实验室也具有吸引力，因为它集成了许多医院和神经科诊所的数字EEG和睡眠多导睡眠图功能。

As neuroscience provides new advances into understanding human brain function, an improved assessment technology is required to characterize the functional neurophysiology of sleep. The fMRI and PET methods of cerebral blood flow imaging face limitations in characterizing sleep organization because their measurement technologies (such as head fixation and loud scanning noise) are problematic for normal sleep. Furthermore, sleep neurophysiology involves many rapid events that must be described with millisecond temporal resolution. We propose to develop the SOMNA (Sleep Organization and Microstates of Neural Arousal) assessment system for dense sensor array electroencephalographic (EEG) studies of sleep. The improved spatial sampling of the 128- and 256- channel EEG will correct an important inadequacy of conventional EEG, promising more accurate anatomical analysis of sleep neurophysiology. The SOMNA system would provide advanced computerized assessment of sleep EEG and polysomnographic measures, and it would segment the EEG into microstates of arousal as well as traditional sleep stages. The system would advance the technology of clinical sleep laboratories, providing new methods of dense array EEG for studies of current density, electrical field animations, and MR-constrained source localization. The improved understanding of sleep physiology may be important to clinical sleep disorders including insomnia, epilepsy, and sleep apnea. PROPOSED COMMERCIAL APPLICATIONS: The ease of testing and interpretation with the SOMNA system will be attractive not only to sleep research centers, but to clinical sleep laboratories, integrating the Digital EEG and Sleep Polysomnography functions in many hospitals and neurology clinics.