COOPERATIVE HUMAN TISSUE NETWORK EASTERN DIVISION

大而长远的目标是提高大学的能力 宾夕法尼亚州医学中心(UPMC)，作为东方医院服务于生物医学研究 美国国家癌症研究所(NCI)合作人体组织分部 网络(CHTN)。东师将通过这次协调， 由5个师组成的国家计划，继续为 通过提供获取人体组织的途径，在全国范围内建立研究基础设施。 具体目标是：(1)提供高质量、有特色的 恶性、良性和正常组织(由经过精心训练的人收集 在严格的安全标准下工作的人员 人类受试者)，用于快速交付(以及标准和定制 患者数据集)到初级(东部分区)和联网(南部、 中西部、西部和儿科/卵巢分部)研究人员。(2)工作 与调查人员(CHTN用户)、科学顾问和研究 社区通过完善 应用程序进程、计算机利用率、协议开发、请求 履行和开具帐单程序。(3)增强网络的实施性 组织需求，特别是大量稀有组织的需求， 或专门采购，采用有针对性的采购办法： 重点领域将包括：(A)最大限度地利用现有场地；(B)增加 建立新机构；(C)开发专门/独特资源。 (4)与CHTN部门和NCI工作人员密切合作，参与 CHTN协调委员会和小组委员会及网络协助 电脑化。(5)提高对人体组织重要性的认识 研究和利用CHTN作为组织资源(着眼于 招募新用户)通过代表参加科学会议， 维护研究人员参考书目，并出版有关 数据。与健康相关：人体组织为健康提供了一个重要的模型 对人类疾病的研究，包括对遗传异常和 癌症的易感性。研究人员被解放出来，可以将更多的时间转移到 他们的研究；诊断的质量控制防止了错误的发现。 设计和方法涉及个性化协议的快速实现； 使用无菌/快速保存标本的专门来源，如下- UP数据(知情同意、关联样本)等；CHTN海关 软件/计算机化网络；使用科学顾问；在线 应用/信息；远程站点计划以最大限度地利用组织 数量/多样性；目标来源：(自体移植骨 骨髓)；新的保存剂，如乳腺癌上皮细胞 停职等；创新资源与志愿健康合作 组织，组织库采集；临床实验室检索，使用 通讯、书目、邮寄等，以提高对 CHTN.

The Broad, long term objective is to enhance the ability of the University of PA Medical Center (UPMC), to serve biomedical research as the Eastern Division of the National Cancer Institute's (NCI) Cooperative Human Tissue Network (CHTN). The Eastern Division will through this coordinated, national program of 5 divisions, continue its contribution to the nationwide research infrastructure by providing access to human tissue. Specific aims are to; (1) Provide high quality, well-characterized malignant, benign, and normal tissue, (collected by carefully trained personnel under exacting safety standards with regard for the rights of human subjects), for rapid delivery (along with standard and customized patient data sets) to primary (Eastern Division) and Networked (Southern, Midwestern, Western and Pediatric/Ovarian Division) researchers. (2) Work with investigators (CHTN users), scientific advisors and the research community to enhance service and ease of access through refinements in the application process, computer utilization, protocol development, request fulfillment and billing procedures. (3) Augment the network's fulfillment of tissue requests, particularly those for large quantities, rare tissues, or specialized procurements, by utilizing a targeted sourcing approach: areas of emphasis will include (a) maximizing existing sites, (b) addition of new institutions, and (c) development of specialized/unique resources. (4) Work closely with CHTN Divisions and NCI staff, participating in the CHTN Coordinating Committee and sub-committees and assisting in Network computerization. (5) Increase awareness of the importance of human tissue to research and of the CHTN as a resource for tissue (with an eye toward recruitment of new users) through representation at scientific meetings, maintenance of a researcher bibliography, and publication of pertinent data. Health Relatedness: Human tissues provide an essential model for the study of human diseases, including research into genetic abnormalities and pre-dispositions in cancer. Researchers are freed to divert more time to their research; quality control of diagnoses prevents erroneous findings. Design and Methods involve rapid fulfillment of individualized protocols; use of specialized sources for sterile/rapidly preserved specimens, follow- up data (informed consent, linked samples), etc; CHTN custom software/computerized networking; use of scientific advisors; on-line applications/information; remote site program to maximize tissue quantities/diversities; targeted sourcing: (autologous transplant bone marrow); new preservations such as breast cancer epithelial cell suspensions etc; innovative resources work with voluntary health organizations, tissue banks acquisition; clinical lab retrievals, use of newsletters, bibliography, mailings, etc., to increase awareness of the CHTN.