ENHANCED CAROTID BIFURCATION PHANTOM FOR MRI/A

颈动脉壁和管腔的非侵入性MR评价受到缺乏全面和解剖学上正确的市售流动体模的阻碍。本项目的目的是开发一种先进的人工颈动脉血流体模，用于开发MRI应用程序，以识别因动脉粥样硬化性颈动脉疾病而有短暂性脑缺血发作或中风风险的患者。该体模结合了现有技术的最佳特征：基于图像数据的创新血管设计（目标1），弹性壁和基质材料以及先进的壁分层构造方法（目标2），以生产灵活的薄壁分支流体模。分支血管在解剖学上是准确的，并将在脉动流下表现出适当的血管扩张和平移（目标3）。第一阶段开发的技术将支持可变的壁弹性，以正确模拟动脉粥样硬化病变。在第二阶段，我们专注于优化在第一阶段确定的组件材料和程序，以期为第三阶段临床试验构建先进的流动模型。一个全面的流动体模将是至关重要的开发，验证和培训医务人员使用最先进的MRI筛查协议的动脉粥样硬化性颈动脉疾病。拟议的商业应用：临床上对无创方法的需求量很大，以识别处于风险中的患者并进行颈动脉手术，而充分的MR工具的商业可用性很有限，因此为针对脑血管疾病的高度先进的拟人流动模型创造了有利可图的市场利基。该项目开发的产品将满足临床研究、质量保证和人员培训应用的当前和未来需求。

Non invasive MR evaluation of the carotid artery wall and lumen is hampered by the lack of a comprehensive and anatomically correct commercially available flow phantom. The objective of this project is to develop an advanced artificial carotid artery flow phantom for use in developing MRI applications to identify patients at risk for transient ischemic attack or strokes due to atherosclerotic carotid artery disease. This phantom combines the best features of existing technologies with: innovative vessel design based on image data (Aim 1), elastic wall and matrix materials and advanced wall layering construction methodology (Aim 2) to produce flexible thin walled branching flow phantoms. Branching vessels are anatomically accurate and will exhibit proper vessel distention and translation under pulsatile flow (Aim 3). Technology developed in Phase I will support variable wall elasticity to properly mimic atherosclerotic lesions. In Phase II, we focus on optimizing component materials and procedures identified in Phase I in anticipation of constructing advanced flow phantoms for Phase III clinical trials. A comprehensive flow phantom will be critical for the development, validation and training of medical personnel on using state of the art MRI screening protocols for atherosclerotic carotid artery disease. PROPOSED COMMERCIAL APPLICATIONS: The magnitude of the clinical need for a non invasive means to identify patients at risk and stage carotid artery surgery is so large and the commercial availability of adequate MR tools so limited as to create a lucrative market niche for highly advanced anthropomorphic flow phantoms targeted at cerebrovascular disease. Products developed from this project will address current and future needs in clinical research, QA, and personnel training applications.