OPTIMIZATION OF KINETICS IN A NOVEL GLUCOSE SENSOR

描述（改编自申请人的摘要）：糖尿病是一种越来越多的 常见的终身疾病糖尿病与许多并发症有关， 估计占所有医疗保健支出的10-15%。 有效的治疗已被证明可以预防或延迟许多相关的 并发症目前最常见的治疗方法包括节食、锻炼和 自我血糖监测（SMBG）。对当前SMBG方法的改进 将使患者能够并鼓励他们更多地监测血糖水平， 密切，改善一般健康和生活质量的糖尿病患者 人口Sensor Technologies Inc.开发了一种微创葡萄糖 传感器.该技术基于一种小型光学传感器植入物， 在光谱的可见光区域中具有荧光，并且可通过 皮肤该传感器对葡萄糖具有高度特异性，并且基于荧光 共振能量转移功能性、耐久性和生物相容性 已经在小动物模型和手持测量设备中得到证实 已完成接下来的步骤要求传感器的动力学 在生理条件下葡萄糖的变化的反应进行了研究。 拟议研究的目标是优化传感器动力学， 并且在不损害传感器生物相容性、寿命和 信噪比 拟议商业应用：不可用

DESCRIPTION (adapted from applicant's abstract): Diabetes is an increasingly common lifelong disease. Diabetes is associated with many complications, and it is responsible for an estimated 10-15% of all health care expenditures. Effective treatment has been shown to prevent or delay many of the associated complications. The most common current treatments include diet, exercise, and self-monitoring of blood glucose (SMBG). An improvement to current SMBG methods would enable and encourage patients to monitor their glucose levels more closely, improving the general health and quality of life of the diabetic population. Sensor Technologies Inc. has developed a minimally invasive glucose sensor. The technology is based on a small optical sensor implant that is fluorescent in the visible region of the spectrum and detectable through the skin. The sensor is highly specific for glucose, and is based upon fluorescence resonance energy transfer. Functionality, durability and biocompatibility have been demonstrated in a small animal model, and a hand-held measurement device has been completed. The next steps require that the kinetics of the sensor response to changes in glucose under physiological conditions be investigated. The goal of the proposed studies is to optimize sensor kinetics both in vitro and in vivo without compromising sensor biocompatibility, lifetime, and signal-to-noise. PROPOSED COMMERCIAL APPLICATION: NOT AVAILABLE