SOLID STATE INTRAOPERATIVE BETA CAMERA

这项提议的目标是开发一种术中贝塔相机(IOBC)原型，专门设计用于成像放射贝塔药物(如18F、124I、186Re和188Re)，这些药物被掺入脑肿瘤或其他器官，如乳房、淋巴结、甲状腺和其他器官。该探头用于术中手术环境。患者在手术前注射肿瘤寻求放射性药物，执行切除肿瘤的外科手术，然后使用IOBC探头对部位进行成像，以定位残留的亚临床肿瘤细胞。拟议的系统旨在通过允许在不过度切除正常组织的情况下更彻底地切除亚临床肿瘤细胞来显著提高肿瘤切除手术的成功率。手术中的Beta相机将使用一个小而轻的可拆卸头部，包括一个1024像素的硅PIN阵列，该阵列对Beta粒子高度敏感，但对噪声伽马背景辐射不敏感。在第一阶段的可行性研究中，我们成功地构建了一个256像素的阵列原型，并从电子噪声、空间分辨率、灵敏度和对Beta发射器响应的一致性方面对其性能进行了表征。该设备的性能与最初预期的一样好，甚至更好。在第二阶段，将设计和开发一套完整的术中成像系统，包括微型探测器、处理电子设备、数据采集、图像处理和显示硬件和软件。该系统将使用加州大学洛杉矶分校医学院的肿瘤模型在现实的临床条件下进行表征。拟议的商业应用：需要商业性的术中成像摄像机来提高肿瘤切除手术的成功率。这可以显著减少手术时间，相应地降低手术成本，并导致更快的恢复和更低的恢复成本。这项工作主要集中在一种新型的半导体β相机系统上，该系统具有可拆卸、紧凑和重量轻的成像探头。不同版本的探头可以适用于乳房、淋巴结、甲状腺和其他器官。

The goal of this proposal is to develop a prototype intraoperative beta camera (IOBC) specifically designed for use in imaging beta emitting radiopharmaceuticals (such as 18F, 124I,186Re, and 188Re) incorporated into tumors in the brain or other organs such as breast, lymph nodes, thyroid and others. The probe is intended for use in the intraoperative surgical environment. The patient is injected with a tumor seeking radiopharmaceutical before surgery, the surgical procedure to remove tumor mass is performed, and the site is then imaged using the IOBC probe to locate residual subclinical tumor cells. The proposed system is intended to significantly improve the success of tumor removal surgeries by allowing more complete removal of subclinical tumor cells without excessive removal of normal tissue. The intraoperative beta camera will use a small and light-weight, detachable head comprising a 1024-pixel silicon-PIN array which is highly sensitive to beta particles but insensitive to the noisy gamma background radiation. During the Phase I feasibility study we successfully constructed a 256- pixel prototype of the array and characterized its performance in terms of electronic noise, spatial resolution, sensitivity, and uniformity of response to beta emitters. The device performed as well or better than was originally expected. In Phase II a complete intraoperative imaging system including miniaturized detector probe, processing electronics, data collection, image processing and display hardware and software will be designed and developed. The system will be characterized under realistic clinical conditions using tumor phantoms at the UCLA School of Medicine. PROPOSED COMMERCIAL APPLICATIONS: There is a need for commercial intraoperative imaging cameras to improve the success of tumor removal surgeries. This could significantly reduce time in surgery with a commensurate decrease in cost of surgery and leading to faster recovery and lower recovery cost. The proposed work is focused on a novel semiconductor beta camera system with detachable, compact, and lightweight imaging probe. Different versions of the probe could be adapted for breast, lymph nodes, thyroid, and other organs.