MOLECULAR NEUROIMAGING OF AIDS DEMENTIA ANIMAL MODELS

该项目的目的是表征体内和体内 体外神经元丢失、神经元功能障碍和脑代谢 艾滋病痴呆综合征（ADC）的动物模型中的异常。 我们对人脑酸性提取物进行了高分辨核磁共振波谱分析， 和非人类灵长类动物。 光谱使我们能够表征 脑中发现的不同代谢物的浓度变化 细胞 我们已经发现ADC以及其他神经退行性疾病 疾病（如皮克病）产生了显着的损失， N-乙酰天冬氨酸（神经元标记物）。 由于高分辨率 我们已经能够量化其他代谢物的光谱质量 如乳酸盐、谷氨酰胺和谷氨酸盐。 这些结果将使我们 为了充分表征体内MRS结果并提供可靠的 解释的基础。

The aim of this project is the characterization of in vivo and in vitro neuronal loss, neuronal dysfunction and brain metabolic abnormalities in an animal model of the AIDS dementia complex (ADC). We have performed HRNMR spectroscopy on acid brain extracts from human and non-human primates. The spectra allow us to characterize the variation in concentration of the different metabolites found in brain cells. We have found that ADC as well as other neurodegenerative diseases (such as Pick's disease) produce a significant loss of N-acetyl-aspartate (a neuronal marker). Due to the high resolution quality of the spectra we have been able to quantify other metabolites such as lactate, glutamine and glutamate. These results will allow us to fully characterize the in vivo MRS results and provide a solid basis for their interpretation.