ENERGY EXPENDITURE IN INFANTS WITH VENTRICULAR SEPTAL DEFECT

患有先天性心脏病和充血性心力衰竭的婴儿经常无法茁壮成长。除了心血管畸形造成的症状和限制外，身体发育迟缓的儿童在智力和运动技能的发展方面也可能滞后。婴幼儿先天性心脏病手术的目的不仅是挽救生命，而且要防止先天性心脏病对生长发育和智力和心理发展的不利影响。准确估计左向右心内分流伴或不伴充血性心力衰竭患者的能量消耗将有助于计划外科手术和优化营养支持。这项研究的目的是确定从左到右分流对3-4个月大婴儿和年龄匹配的健康对照组的总每日能量消耗的影响，以及总能量消耗在基础代谢过程中的比例。了解这些患者的能量消耗对于准确评估他们的能量需求、提供最佳营养支持和优化手术矫正时机是必要的。将在手术前后对婴儿进行研究，以检查手术修复带来的这些参数的变化。

Infants with congenital heart disease and congestive heart failure frequently experience failure to thrive. In addition to the symptoms and limitations imposed by the cardiovascular malformation, the child with delayed physical development may also lag in the development of mental and motor skills. The goal of surgery in infants and children with congenital heart disease is not only the saving of life but also prevention of the adverse effects of congenital heart disease on growth and intellectual and psychological development. An accurate estimate of energy expenditure of patients with left-to-right intracardiac shunts with or without congestive heart failure would be helpful in planning surgical procedures and optimizing nutritional support. The purpose of the proposed research is to determine the effect of left to right shunting on the total daily energy expenditures and the proportion of that total expended on basal metabolic processes in a group of 3-4 month old infants and group of healthy age-matched controls. Knowledge of the energy expenditures of these patients is necessary to accurately gauge their energy requirements, provide optimal nutritional support and optimize the timing of surgical correction. Infants will be studied before and after surgery to examine changes in these parameters brought about by surgical repair.