STRUCTURE & INHIBITION OF HIV 1 INTEGRASE

我们目前正在尝试延长衍射极限。 以上HIV-1整合酶晶型等，通过筛选不同的 结晶添加剂、抑制剂、底物和低温 人造母液。因为绕射显著地 通过使用同步辐射改进，SSRL时间明显 项目续展所需。下面的实验将是 进行了以下工作：1)筛选提高衍射率的条件 HIV-1整合酶晶体的极限。2)最低限度，高收 聚乙二醇乙二醇单晶体生长的分辨率数据 抑制剂和晶体A。

We are currently attempting to extend the diffraction limit of the above HIV-1 integrase crystal forms, and others, by screening various crystallization additives, inhibitors, substrate, and cryogenic artificial mother liquors. Since diffraction is significantly improved by the use of synchrotron radiation, SSRL time is clearly required for project continuation. The following experiments will be carried out: 1)Screen for conditions which improve the diffraction limit of the HIV-1 integrase crystals. 2)Minimally, collect high resolution data from apo-crystal B grown in PEG with and without inhibitor, and crystal A.