MODELING OF WATER FLUXES

过去尝试对心脏和心脏的水交换进行建模 其他灌流良好的器官利用相对简单，通常 单舱模型。既不是区隔模式，也不是简单的 轴向分布模型可以很好地拟合高分辨率数据。 这两种模型都给出了毛细渗透率-表面的估计值。 区域产品是不现实的，但出于不同的原因。为 溶质在其流动速度上几乎是受限的 血液-组织交换，PS估计因两种方法不同而不同。 渗透瞬变水通量往往受到跨膜的限制。 亲水性溶质的通量，而不是通过水的渗透性，因此 考虑任何净水通量的模型也必须考虑到 溶质通量。在这个项目中，我们将把 水和溶质通量控制现象的描述 血流灌注良好的器官，从而协调不同的估计 用不同的实验方法和方法获得的渗透率 分析技术。该项目将先前的项目扩展到 示踪剂水交换与示踪剂和非示踪剂的广泛溶质 分子大小的范围；后面的模型将描述示踪剂和 非示踪剂水在非示踪剂水净通量期间。

Past attempts at the modeling of water exchanges in the heart and other well-perfused organs have utilized relatively simple, usually single compartmental models. Neither compartmental models nor simple axial distributed models can be fitted well to high resolution data. Both model forms give estimates of the capillary permeability-surface area products which are unrealistic, but for different reasons. For solutes that are very nearly flow-limited in their rates of blood-tissue exchange, the PS estimates differ by the two approaches. Osmotic transient water fluxes tend to be limited by the transmembrane fluxes of hydrophilic solutes, not by water permeability, therefore models accounting for any net water flux must also account for the solute fluxes. In this project we will bring together the descriptions of the phenomena governing water and solute fluxes in well-perfused organs, and thereby reconcile the disparate estimates of permeabilities obtained by using different experimental an d analytical techniques. This project extends previous projects on tracer water exchanges and tracer and non-tracer solutes of a wide range of molecular sizes; the later models will describe tracer and non-tracer water during net fluxes of non-tracer water.