PATH MODEL FOR HIPPOCAMPAL NEOCORTICAL INTERACTIONS IN MEMORY & EPILEPSY

申请启动资金以开始基因分析 编码最近发现的核仁蛋白BN 46151（Trimbur & 沃尔什，1992，细胞科学杂志。103：167; Trimbur &沃尔什，1993，细胞生物学杂志 Biol. 122：753）。 BN 46151是不寻常的，因为它似乎结合到 微管 目前的项目旨在描述 这种蛋白质的结构和功能。 我们目前正在测序 编码BN 46151的克隆，我们需要请求的计算机 资源来分析和组装这些序列。 一旦完成 BN 46151基因的序列是可用的，它将用于开发 使用在体外表达的重组蛋白和在体外表达的重组蛋白进行功能分析。 和体内。

A starter grant is requested to begin the analysis of the gene encoding the recently discovered nucleolar protein BN46151 (Trimbur & Walsh, 1992, J. Cell Sci. 103: 167; Trimbur & Walsh, 1993, J. Cell Biol. 122: 753). BN46151 is unusual in that it appears to bind to microtubules. The current project is directed at characterizing the structure and function of this protein. We are currently sequencing clones that encode BN46151 and we need the requested computer resources to analyze and assemble these sequences. Once the complete sequence of the BN46151 gene is available, it will be used to develop functional analyses using recombinant proteins expressed both in vitlo and in vivo.