STRUCTURE & FUNCTION OF BACTERIAL VIRUSES

我们已经测定了一个噬菌体基因组的DNA序列 并将确定另外大约10个，还有大约15个可用的 在公共数据库中。我们将使用PSC设施来组装我们的DNA 测序数据以产生完成的序列，然后分析这些 序列。分析将包括，首先，对个人的分析 决定个体遗传结构的基因组序列 病毒，第二，新确定的 GenBank数据库中的序列和其他DNA序列 特别是，我们将重点比较相关的噬菌体 序列，在单个基因和蛋白质水平上，在 整个基因组的水平。从这些比较中获得的信息将 解决病毒中结构/功能关系的问题 蛋白质和遗传机制在病毒进化中的作用 基因组。

We have determined the DNA sequence of one bacteriophage genome and will determine about ten more, and roughly 15 more are available in public databases. We will use PSC facilities to assemble our DNA sequence data to produce finished sequences and then to analyze those sequences. Analysis will include, first, analysis of individual genome sequences to determine the genetic structure of the individual viruses and , second, comparisions among the newly determined sequences and other DNA sequences in the GenBank database In particular, we will focus on comparisons between related bacteriophage sequences, at the level of individual genes and proteins and at the level of the entire genomes. Information from these comparisons will address issues of structure/function relationships in the viral proteins and of genetic mechanisms operating in the evolution of viral genomes.