MOLECULAR GENETICS OF TUMOR VIRUSES AND CELLS

描述(申请人描述)：拟议的培训计划的目的是为高素质的男性和女性在与癌症相关的基础生物医学研究中的创造性职业生涯做准备。与过去一样，该计划的主要重点是肿瘤病毒和细胞的分子遗传学方面的研究培训。该项目的教职员工是约翰·霍普金斯大学分子生物学和遗传学系的成员。他们的研究兴趣包括：DNA肿瘤病毒基因组的复制，生长因子和癌基因对细胞增殖的调控，哺乳动物细胞周期的控制，正常和肿瘤生长中基因表达的调控，反转录转座子的分子遗传学，细胞信号转导机制，以及蛋白质-核酸相互作用的原理。大多数教职员工都得到了NCI或美国癌症协会(ACS)的直接研究支持。一名教职员工拥有ACS教授学位，两名教职员工拥有ACS教研奖。该项目将包括博士后(8名)和博士后(4名)实习生。博士前实习生必须在定量科学方面有扎实的背景和突出的本科成就，最好是现代生物学包括遗传学方面的一些背景。他们必须首先被约翰·霍普金斯大学医学院生物化学、细胞和分子生物学的跨部门研究生计划录取，并且必须满意地完成该计划的第一年课程和实验室轮换。在第一年结束时，学生被选入肿瘤病毒和细胞分子遗传学课程，平均每年大约两人，稳定数量为八人。他们其余的培训包括旨在鼓励创造力和自力更生的实验室研究，与基础癌症研究相关的必修选修课，现代分子遗传学技术的实践指导，以及参加研究研讨会和期刊俱乐部。该大学任何分校开设的所有课程都对学生开放。博士后实习生必须完成博士或医学博士学位的要求，并必须在基础或临床水平的癌症相关研究方面具有突出的成就和创造性职业生涯的潜力。他们几乎所有的时间都在一名参与该项目的教职员工的密切监督下进行个人研究项目。他们还积极参加由整个项目人员参加的研究研讨会和杂志俱乐部，并在适当的情况下，参加大学内提供的与癌症生物学有关的正式课程。主要的培训设施设在约翰霍普金斯大学医学院分子生物学和遗传学系内，由现代研究实验室、各种辅助设施、报告室和研讨会以及一个图书馆组成。

DESCRIPTION (Applicant's Description): The purpose of the proposed training program is to prepare highly qualified men and women for creative careers in basic biomedical research related to cancer. As in the past, a primary emphasis of the program is research training in the molecular genetics of tumor viruses and cells. The faculty of the Program are members of the Department of Molecular Biology and Genetics at Johns Hopkins. The research interests represented among the faculty include: the replication of DNA tumor virus genomes, the regulation of cellular proliferation by growth factors and oncogenes, the control of the mammalian cell cycle, the regulation of gene expression in normal and neoplastic growth, the molecular genetics of retrotransposons, the mechanisms of cellular signal transduction, and the principles of protein-nucleic acid interactions. A majority of the faculty receives direct research support from the NCI or the American Cancer Society (ACS). One faculty member holds an ACS Professorship and two hold ACS Faculty Research Awards. The program will include both predoctoral (8) and postdoctoral (4) trainees. Predoctoral trainees must have a strong background and outstanding undergraduate accomplishment in quantitative science, and preferably some background in modern biology including genetics. They must first be accepted into the interdepartmental Graduate Program in Biochemistry, Cellular and Molecular Biology at the Johns Hopkins University School of Medicine and must satisfactorily complete the first year course and laboratory rotations of that program. At the end of the first year students are selected for admission into the Program in Molecular Genetics of Tumor Viruses and Cells at an average rate of about two per year with a steady state number of eight. The remainder of their training consists of laboratory research designed to encourage creativity and self-reliance, required elective coursesrelated to basic cancer research, practical instruction in the techniques of modern molecular genetics, and participation in research seminars and journal clubs. All courses given by any branch of the University are open to their students. Postdoctoral trainees must have completed the requirements for the Ph.D. or M.D. and must have outstanding accomplishment and potential for creative careers in cancer-related research at a basic or clinical level. They spend almost all of their time carrying out an individual research project under the close supervision of a faculty member participating in the program. They also participate actively in research seminars and journal clubs involving the entire program personnel and, as appropriate, take a formal course related to cancer biology offered within the University. The primary training facilities are located within the department of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine and consist of modern research laboratories, a variety of support facilities, lecture and seminar rooms and a library.