INTERACTIONS OF STAVUDINE WITH DRUGS USED TO PREVENT OPPORTUNISTIC INFECTIONS

抗逆转录病毒药物与药物相互作用研究综述 用于预防机会性感染的药物越来越受到重视。 大多数研究都评估了双向互动，尽管事实是 大多数患者同时接受多种药物治疗。这项研究评估了 多药相加和序贯给药对大鼠心脏功能的影响 肝代谢药物司他夫定的药代动力学。 司他夫定已被证明对血浆没有显著影响 利福布汀、土霉素或氟康唑的水平。相反，那些 药物对司他夫定水平没有影响。

Summary of Work: The interactions of anti-retroviral agents with drugs used to prevent opportunistic infections are increasingly appreciated. Most studies have evaluated two-way interactions despite the fact that most patients receive multiple drugs simultaneously. This study assesses the effect of multiple drugs additively and sequentially on the pharmacokinetics of stavudine, a hepatically metabolized drug. Stavudine has been shown to have no significant effects on the plasma levels of rifabutin, dauthromycin, or fluconazole. Conversely, those drugs have no influence on stavudine levels.