STUDIES OF PHENOLPHTHALEIN CONTAINING LAXATIVE USE AND NEOPLASIA

工作总结：酚酞，许多泻药中的一种成分， 在2年的喂养研究中显示出明确的致癌活性证据 最近由国家毒理学计划（NTP）完成的啮齿动物研究。 大约3%的美国老年人使用含酚酞的 每天服用泻药 我们将研究 使用含酚酞的泻药有患卵巢癌的风险， 结直肠腺瘤性息肉。 我们已经与委托人签订了合作协议， 研究人员正在进行两项关于危险因素的病例对照研究， 卵巢癌 在我们的鼓动下，这些调查人员 在他们的调查表中增加了两页， 特定的含酚酞的泻药。 每项研究都会产生 大约300个病例和300个对照，数据将准备好进行分析。 1999年 两项危险因素病例对照研究的数据收集 结直肠腺瘤性息肉已经完成。 泻药使用数据 可用于两项研究。 我们已经研究了泻药的使用， 与息肉风险的关系。 息肉与 使用所有泻药和含酚酞的泻药， 在考虑了饮食和其他风险后， 结直肠腺瘤的发病因素 这两项研究的结果是 彼此不一致，但总体上对 含酚酞泻药的使用与 息肉

Summary of Work: Phenolphthalein, a constituent in many laxatives, showed clear evidence of carcinogenic activity in 2-year feeding studies in rodents recently completed by the National Toxicology Program (NTP). About 3% of the older U.S. population uses phenolphthalein-containing laxatives on a daily basis. We will investigate the relation of phenolphthalein-containing laxative use with risk of ovarian cancer and adenomatous colorectal polyps in humans. We have established collaborative agreements with the principal investigators for two ongoing case-control studies of risk factors for ovarian cancer. At our instigation, these investigators have inserted into their questionnaire a 2-page addition that ascertains use of specific phenolphthalein-containing laxatives. Each study will yield about 300 cases and 300 controls, and the data will be ready for analysis in 1999. Data collection for two case-control studies of risk factors for adenomatous colorectal polyps have been completed. Data on laxative use were available for both studies. We have examined laxative use in relation to risk of polyps in these data. The association of polyps with use of all laxatives and phenolphthalein-containing laxatives was specifically explored after taking into account dietary and other risk factors for colorectal adenomas. Results from the two studies were inconsistent with each other but overall offered little support for an association between phenolphthalein-containing laxative use and risk of polyps.