GASP--A SOFTWARE TOOL FOR METHODOLOGIC DEVELOPMENT IN STATISTICAL GENETICS

开发用于统计遗传分析的计算机软件可以 通过软件工具的可用性来促进，这些软件工具可用于1） 验证算法，2）确定经验I类错误率，3） 确定测试的功效，以及4）确定 关于基本假设失败的测试。基因组学 分析模拟程序（G.A.S.P.）是一个软件工具， 基于用户指定的模型生成族数据样本。两 可以生成性状和标记数据。生成的数据可以如此简单 作为一个随机个体的单一样本，或复杂到数千个 基于线性组合性状的大家系样本 主基因、多基因、共同亲缘环境和协变量 件.

Development of computer software for statistical genetic analysis can be facilitated by the availability of software tools that can be used to 1) verify the algorithms, 2) determine empirical type I error rates, 3) determine the power of a test, and 4) to determine the robustness of a test with respect to failures of underlying assumptions. The Genometric Analysis Simulation Program (G.A.S.P.) is a software tool that can generate samples of family data based on user-specified models. Both trait and marker data can be generated. Data generated can be as simple as a single sample of random individuals, or as complex as thousands of samples of extended families with traits based on a linear combination of major locus, polygenic, common sibship environment and covariate components.