课题基金 / 基金详情

COEXISTENCE OF PEPTIDES AND NEUROTRANSMITTERS--CALRETININ IN NEUROGLIOMA

COEXISTENCE OF PEPTIDES AND NEUROTRANSMITTERS--CALRETININ IN NEUROGLIOMA
神经胶质瘤中肽与神经递质的共存——钙维A蛋白
批准号：
6162825
负责人：
D M JACOBOWITZ
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6162825
关键词：
RNase protection assay brain cell calcium binding protein cell proliferation immunocytochemistry in situ hybridization neoplastic cell culture for noncancer research neurochemistry neuropeptides neurotransmitter biosynthesis neurotransmitters

项目摘要

项目成果

D M JACOBOWITZ的其他基金

相似基金

相关文献

中文摘要
翻译
我们一直在研究神经胶质瘤脑癌细胞在 文化。我们通过免疫组织化学发现，Calretinin是 存在于神经胶质瘤细胞中。通过凝胶电泳法和 免疫印迹法，我们还观察到两种钙调蛋白的阳性条带 和钙结合蛋白。这表明这两种钙结合 这些神经胶质瘤细胞中的蛋白质共存。通过核糖核酸酶保护 实验中我们发现了Calretinin mRNA的存在。我们推测 Calretinin可能参与了这些癌细胞的增殖。 细胞。
英文摘要
We have been studying neuroglioma brain cancer cells that grow in culture. We have found, by immunohistochemistry, that calretinin is present in the neuroglioma cells. By gel electrophoresis and immunoblotting, we have also observed a positive band of both calretinin and calbindin. This would suggest that both these calcium binding proteins coexist in these neuroglioma cells. By ribonuclease protection assay we have revealed the presence of calretinin mRNA. We speculate that calretinin may be involved in cell proliferation of these cancer cells.
期刊论文(1)
专著(0)
科研奖励(0)
会议论文
LOCALIZATION AND CHARACTERIZATION OF BRAIN NEUROPEPTIDES
STUDIES OF CALRETININ IN PERIPHERAL ORGANS AND CELLS
COEXISTENCE OF PEPTIDES AND NEUROTRANSMITTERS
AUTOIMMUNE ASPECTS OF DISEASE
海外基金