INTERDISCIPLINARY TRAINING PROGRAM IN MUSCLE BIOLOGY

该计划旨在提供跨学科的肌肉训练 为博士前和博士后学生提供生物学课程。该计划将强调 骨骼肌、心肌和平滑肌的功能特性。 我们 16名教师来自学校的4个基础科学部门 医学部，马里兰州大学巴尔的摩分校，以及 马里兰州大学工程学院 巴尔的摩县。 为了反映教师背景的多样性， 提供的培训将从分子生物学决定因素， 肌肉发育和分子方面的结构和功能， 肌肉蛋白质通过肌肉细胞骨架的细胞生物学方面 以及个体肌肉的基质、生物物理和生理分析 细胞功能和生物力学性能的整体肌肉和肌肉 机关 我们的教师是国内和国际公认的 钙控制肌肉功能和肌肉细胞骨架的区域， 矩阵我们的学生将接受这些以及各种方面的培训 相关领域，重点是使用几个互补的 技术来处理每个调查中的问题。主要 博士前培训的教学方面将扩大 关于肌肉的跨学科课程，已经定期提供， 该计划教师，并已深受过去的学生 组 我们建议开始与1个博士前和2个博士后程序 第一年的受训人员增加到2名博士前和3名博士后， 第二年，到第三年的2个预科和4个博士后，然后 第四年达到3名博士后和4名博士后的稳定状态 和第五年。进入博士前培训生将有一个坚实的 生物学，化学和/或物理学背景，优异的GRE成绩， 强有力的推荐信。即将到来的博士后培训生将 我已经完成了一个坚实的博士论文，并有强烈的信 推荐来自该计划的学员将准备带来一个 广泛的方法来回答肌肉的基本问题 生物学和肌肉疾病及其可能治疗的基础 或最终治愈 因此，该方案满足了国家的需要， 胜任的多学科肌肉功能研究者， 疾病

This program is designed to provide interdisciplinary training in muscle biology for pre- and postdoctoral students. The program will emphasize the functional properties of skeletal, cardiac and smooth muscle. Our 16 faculty members come from 4 basic science departments at the School of Medicine, University of Maryland at Baltimore, and 1 department in the College of Engineering at our sister campus, University of Maryland Baltimore County. Reflecting this diversity of faculty' backgrounds, the training offered will range from the molecular biological determinants of muscle development and molecular aspects of structure and function of muscle proteins through cell biological aspects of muscle cytoskeleton and matrix, biophysical and physiological analysis of individual muscle cell function and biomechanical properties of whole muscles and muscular organs. Our faculty is nationally and internationally recognized in the areas of calcium control of muscle function and muscle cytoskeleton and matrix. Our students will receive training in these and in a variety of related areas, with emphasis on the use of several complimentary techniques to approach each question under investigation. The major didactic aspect of the predoctoral training will be an expanded interdisciplinary course on muscle that is already regularly offered by the program faculty and which has been well received by past student groups. We propose to begin the program with 1 predoctoral and 2 postdoctoral trainees in the first year, increase to 2 pre- and 3 postdoctorals in the second year, to 2 pre- and 4 postdoctorals in the third year and then reach a steady state of 3 pre- and 4 postdoctoral trainees in the fourth and fifth years. Entering predoctoral trainees will have a solid background in biology, chemistry and/or physics, excellent GRE scores and strong letters of recommendation. Incoming postdoctoral trainees will have completed a solid PhD thesis and have strong letters of recommendation. Trainees from this program will be prepared to bring a wide range of approaches to bear on answering basic questions in muscle biology and on the bases for muscle diseases and their possible treatment or eventual cure. The program therefore serves a national need for competent multi-disciplinary investigators of muscle function and disease.