HEALTH HAZARDS FROM GROUNDWATER CONTAMINATION

该申请要求资金继续生物医学和生态工程 旨在更好地了解潜在健康危害的研究 由于地下水和土壤受到化学品的污染， 在危险废物场发现的 正在调查的污染物包括 挥发性有机溶剂如苯和三氯乙烯， 环境持久性化合物，如多氯联苯和多环芳烃。 一行23 来自密歇根州立大学、密歇根大学和 普渡大学将进行一项合作和综合研究， 涉及16个研究项目。 污染治理研究 污染场地包括生物降解过程的基础研究， 使用化学改性粘土吸附和催化破坏 污染物。 挥发性有机化合物在土壤中的迁移 地下进行了实验研究和完善的数学模型 描述这种运动是为了预测 清理前后的环境浓度。 生物医学科学家正在研究同样的毒性机制 选定的化学品组。 将包括化学诱导的 涉及嗜中性粒细胞、生殖系统和 细胞间通讯和其它基本细胞调节 流程. 此外，各种生物系统被用来 确定生态工程过程中产生的产品的潜在毒性 细菌和化学降解的研究。 一个新的系统来评估 将开发多氯联苯和多环芳烃混合物的生物活性 使用基因工程技术。 这项研究将产生几个新的， 灵敏的生物测定/生物标志物系统，用于检测和监测 卤代芳烃。 在开展研究工作的同时，还开展了培训工作， 毒理学教育的研究生和博士后研究员参与 在场地修复研究中。

This application requests funds to continue biomedical and ecoengineering research directed toward a better understanding of potential health hazards arising from contamination of groundwater and soils with chemicals commonly found at hazardous waste sites. The pollutants under investigation include volatile organic solvents such as benzene and trichloroethylene and environmentally persistent compounds such as PCBs and PAHs. A group of 23 scientists from Michigan State University, the University of Michigan and Purdue University will engage in a collaborative and integrated research program involving 16 research projects. Research on remediation of contaminated sites includes basic studies of biodegradation processes and the use of chemically modified clays to adsorb and catalyze the destruction of pollutants. The transport of volatile organic compounds in the subsurface is studied experimentally and refined mathematical models describing this movement are being developed for use in predicting environmental concentrations before and after clean-up. Biomedical scientists are examining the mechanisms of toxicity of the same selected group of chemicals. Included will be studies of chemical-induced toxicity involving neutrophils, the reproductive system, and inhibition of intercellular communication and other fundamental cellular regulation processes. In addition, various biological systems are employed to determine the potential toxicity of products produced during ecoengineering studies of bacterial and chemical degradation. A novel system to assess the biological activity of mixtures of PCBs and PAHs will be developed using genetic engineering techniques. The study will produce several new, sensitive bioassay/biomarker systems for detection and monitoring of halogenated aromatic hydrocarbons. The research effort is accompanied by a training component which provides toxicology education to graduate students and postdoctoral fellows involved in site remediation research.